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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents findings on the efficacy and safety of a shift from alendronate (ALN) to denosumab (DMAb) in a subset of women from the 1-year Study of Transitioning from Alendronate to Denosumab [STAND; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00377819\u0026amp;atom=%2Fspmdc%2F11%2F5%2F13.2.atom\u0022\u003ENCT00377819\u003C\/a\u003E] trial who transitioned to DMAb after 5 or more years of continuous ALN therapy.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMetabolic Bone Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMenopause\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EHenry G. Bone, MD, Michigan Bone and Mineral Clinic, Grosse Pointe, Michigan, USA, presented findings on the efficacy and safety of a shift from alendronate (ALN) to denosumab (DMAb) in a subset of women from the 1-year Study of Transitioning from Alendronate to Denosumab (STAND; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00377819\u0026amp;atom=%2Fspmdc%2F11%2F5%2F13.2.atom\u0022\u003ENCT00377819\u003C\/a\u003E) trial who transitioned to DMAb after 5 or more years of continuous ALN therapy.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ESTAND was a multicenter, international, randomized, double-blind, double-dummy study in 504 postmenopausal women aged \u226555 years with a bone mineral density (BMD) score of \u2264\u20132.0 and \u2265\u20134.0 or more who had been receiving ALN therapy for at least 6 months. Subjects were randomly assigned to either continued weekly ALN treatment or subcutaneous denosumab 60 mg every 6 months and were followed for 12 months. The primary endpoint was noninferiority of DMAb compared with ALN [Kendler DL. \u003Cem\u003EJ Bone Min Res\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EAt Month 12, total hip BMD increased by 1.9% in the DMAb group versus 1.05% in the ALN group (p\u0026lt;0.0001). DMAb subjects also showed significantly greater BMD gains compared with ALN at the lumbar spine, femoral neck, and 1\/3 radius (all p\u0026lt;0.0125). Median serum c-telopeptide levels were significantly decreased in the DMAb group compared with the ALN group (p\u0026lt;0.0001) at all time points. Adverse events (AEs) and serious AEs were balanced between groups. No clinical hypocalcemic AEs were reported [Kendler DL. \u003Cem\u003EJ Bone Min Res\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EIn STAND, 149 women aged 70.0 \u00b1 7.6 years had received ALN for \u22655 years. These women were slightly older and had worse hip but not spine BMD than those who were treated with ALN for \u0026lt;5 years. A total of 70 women transitioned to DMAb, and 79 women remained on ALN. Transitioning to DMAb for 12 months led to further significant increases in BMD of 2.95% (lumbar spine), 1.66% (total hip), and 1.02% (femoral neck). Those who remained on ALN had smaller changes in BMD of 1.55% (lumbar spine), 0.97% (total hip), and 0.25% (femoral neck). An interaction-by-subgroup analysis showed that the greater gains in BMD in the transition-to-DMAb subgroup that was exposed to ALN for \u22655 years were consistent with overall population results. Of the women who received ALN for \u22655 years, a similar number of AEs were reported in those who transitioned to DMAb and those who continued to receive ALN (81.4% and 84.8%, respectively). The most frequently reported AEs for both groups combined were nasopharyngitis (16.1%), back pain (11.4%), nausea (7.4%), bronchitis (7.4%), pain in the extremities (7.4%), and arthralgia (7.4%). There were no cases of osteonecrosis of the jaw, delayed fracture healing, or atypical femoral fractures.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EAccording to Dr. Bone, results from the STAND follow-up study are consistent with those from the overall STAND study\u2014ie, that the transition to DMAb after \u22655 years of continuous ALN treatment led to further significant gains in BMD at the lumbar spine, total hip, and femoral neck\u2014and demonstrated a similar safety profile compared with patients who continued on ALN.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/5\/13.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn28q\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}