<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alexander, Lori</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Biller, Beverly M.K.</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Pasireotide May Provide Option for Medical Therapy Targeting the Underlying Cause of Cushing Disease</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">12-12</style></pages><abstract><style  face="normal" font="default" size="100%">A Phase 3 trial showed that pasireotide, a multireceptor-targeted somatostatin analog, led to rapid and sustained decreases in cortisol levels and provided clinical benefit in patients with Cushing disease. Surgery is the first-line treatment for this disease, and most current medical options block adrenal cortisol production but do not treat the underlying disease. Pasireotide may provide the first reliable pituitary-directed medical therapy that targets the underlying cause of Cushing disease.</style></abstract><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">11</style></volume></record></records></xml>