RT Journal Article
SR Electronic
A1 Alexander, Lori
T1 Human Recombinant Leptin for Treatment of Hypothalamic Amenorrhea
JF MD Conference Express
YR 2011
FD SAGE Publications
VO 11
IS 5
SP 9
OP 9
DO 10.1177/155989771105003
UL http://mdc.sagepub.com/content/11/5/9.abstract
AB Hypothalamic amenorrhea due to strenuous exercise or chronic energy deficiency is associated with the dysfunction of the hypothalamic-pituitary-peripheral axes, resulting in infertility, bone loss, and stress fractures. The findings of a pilot randomized controlled trial showed that long-term treatment with human recombinant leptin (metreleptin) improved neuroendocrine and reproductive function in women with exercise-induced hypothalamic amenorrhea and low levels of circulating leptin.