PT  - JOURNAL ARTICLE
AU  - Alexander, Lori
TI  - Human Recombinant Leptin for Treatment of Hypothalamic Amenorrhea
DP  - 2011 Sep 01
TA  - MD Conference Express
PG  - 9--9
VI  - 11
IP  - 5
4099  - http://mdc.sagepub.com/content/11/5/9.short
4100  - http://mdc.sagepub.com/content/11/5/9.full
AB  - Hypothalamic amenorrhea due to strenuous exercise or chronic energy deficiency is associated with the dysfunction of the hypothalamic-pituitary-peripheral axes, resulting in infertility, bone loss, and stress fractures. The findings of a pilot randomized controlled trial showed that long-term treatment with human recombinant leptin (metreleptin) improved neuroendocrine and reproductive function in women with exercise-induced hypothalamic amenorrhea and low levels of circulating leptin.