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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe primary objective of The Action for Health in Diabetes [Look AHEAD] Trial is to examine the long-term effects of an intensive lifestyle intervention that is designed to achieve and maintain weight loss by decreasing caloric intake and increasing physical activity in overweight or obese volunteers with type 2 diabetes. Participants in this program will be compared with controls who are involved in diabetes support and education (usual care).\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiometabolic Disorder\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPrevention \u0026amp; Screening\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe primary objective of The Action for Health in Diabetes (Look AHEAD) Trial is to examine the long-term effects of an intensive lifestyle intervention (ILI) that is designed to achieve and maintain weight loss by decreasing caloric intake and increasing physical activity in overweight or obese volunteers with type 2 diabetes. Participants in this program will be compared with controls who are involved in diabetes support and education (DSE, usual care).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EA multicenter, randomized, controlled trial on the long-term (13.5 years) effects of ILI on cardiovascular morbidity and mortality (ie, the incidence of cardiovascular disease [CVD], death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization) in this population. The study includes 5145 participants and is planned through June 30, 2015.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EXavier Pi-Sunyer, MD, St. Luke\u0027s Roosevelt Hospital Columbia University, New York, New York, USA, described the study design in detail, as well as key results over 4 years [Look AHEAD Research Group et al. \u003Cem\u003EDiabetes Care\u003C\/em\u003E 2007; Look AHEAD Research Group et al. \u003Cem\u003EArch Intern Med\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAveraged across 48 months, ILI participants had a greater percentage of weight loss than DSE participants (\u22126.15% vs \u22120.88%; p\u0026lt;0.001) and greater improvements in treadmill fitness (12.74% vs 1.96%; p\u0026lt;0.001), HbA1C level (\u22120.36% vs \u22120.09%; p\u0026lt;0.01), systolic (\u22125.33 vs \u22122.97 mm Hg; p\u0026lt;0.001) and diastolic (\u22122.92 vs \u22122.48 mm Hg; p=0.1) blood pressure, and levels of high-density lipoprotein cholesterol (3.67 vs 1.97 mg\/dL; p\u0026lt;0.001) and triglycerides (\u221225.56 vs \u221219.75 mg\/dL; p\u0026lt;0.001) [Look AHEAD Research Group et al. \u003Cem\u003EArch Intern Med\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EReductions in low-density lipoprotein cholesterol were greater in DSE than ILI participants (\u221212.84 vs \u221211.27 mg\/dL; p=0.009), due to greater use of lipid-lowering medications in the DSE group. At 4 years, ILI participants maintained greater improvements than DSE participants in weight, fitness, HbA1C levels, systolic blood pressure, and high-density lipoprotein cholesterol levels [Look AHEAD Research Group et al. \u003Cem\u003EArch Intern Med\u003C\/em\u003E 2010].\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/8\/32.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn1s3\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}