Reproduced with permission from The Lancet; Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials; Cholesterol Treatment Trialists'; Nov 13, 2010;376(9753):1670–1680.
Reproduced with permission from the American College of Cardiology; Can Low-Density Lipoprotein Be Too Low? The Safety and Efficacy of Achieving Very Low Low-Density Lipoprotein With Intensive Statin Therapy; Wiviott SD et al. J Am Coll Cardiol 2005;46(8):1411–1416.