PT  - JOURNAL ARTICLE
AU  - Buckley, Rita
ED  - Mouton, Johan W.
TI  - Preventing Resistance — The Role of Optimized Dosing
DP  - 2011 Dec 01
TA  - MD Conference Express
PG  - 19--20
VI  - 11
IP  - 12
4099  - http://mdc.sagepub.com/content/11/12/19.short
4100  - http://mdc.sagepub.com/content/11/12/19.full
AB  - The rapid emergence of antibiotic resistance is a major public health concern [Zhang L et al. Appl Environ Microbiol 2011]. This article discusses five questions of resistant bacteria in the gut: Their possible presence without antibiotic exposure; Whether there is selection of resistant gut bacteria during antimicrobial exposure; Whether there is selection of resistance during systemic treatment for other infections; Whether it is possible to avoid or minimize selection; How optimization of treatment relates to selection of resistance in the gut.