RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 JAK2 Reduces Basal Synthesis of Collagen in SSc Fibroblasts
JF MD Conference Express
YR 2011
FD SAGE Publications
VO 11
IS 13
SP 16
OP 16
DO 10.1177/155989771113009
UL http://mdc.sagepub.com/content/11/13/16.abstract
AB This article discusses a study that explored the potential role of Janus kinase 2 (JAK2) as a molecular target for the treatment of fibrotic disease. In this study, inhibition of JAK2 reduced the basal synthesis of collagen selectively in systemic sclerosis fibroblasts but not in control fibroblasts.