PT - JOURNAL ARTICLE AU - Vinall, Maria ED - Burmester, Gerd-RĂ¼diger TI - Tofacitinib in Patients with Active RA with an Inadequate Response to Tumor Necrosis Factor Inhibitors DP - 2011 01 TA - MD Conference Express PG - 11--12 VI - 11 IP - 13 4099 - http://mdc.sagepub.com/content/11/13/11.short 4100 - http://mdc.sagepub.com/content/11/13/11.full AB - An oral Janus kinase inhibitor, in combination with methotrexate, led to significant improvements in a treatment-refractory rheumatoid arthritis population with no significant safety concerns. This article discusses the Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of 2 Doses of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate With Inadequate Response to TNF Inhibitors study [ORAL Sync; NCT00960440].