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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe Randomized Evaluation of a Novel Bioabsorbable Polymer-Coated, Everolimus-Eluting Coronary Stent [EVOLVE] trial compared the bioabsorbable polymer SYNERGY Everolimus-Eluting Coronary Stent System with the permanent polymer PROMUS Element Stent for the treatment of de novo atherosclerotic lesions.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EDurable polymer coatings on drug-eluting stents are associated with chronic inflammation and impaired healing. The reduced polymer load and short-term polymer exposure of bioabsorbable polymer stents may reduce duration of dual antiplatelet therapy (DAPT), reduce risk with DAPT interruption, and decrease stent thrombosis.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe SYNERGY stent has a PLGA bioabsorbable polymer coating plus everolimus that is applied only to the abluminal surface of a thin-strut platinum chromium stent. Once implanted, the polymer coating completely resorbs within 4 months. The Randomized Evaluation of a Novel Bioabsorbable Polymer-Coated, Everolimus-Eluting Coronary Stent (EVOLVE) trial, presented by Ian Meredith, MBBS, PhD, Monash Medical Centre and Southern Health, Melbourne, Australia, compared the bioabsorbable polymer SYNERGY Everolimus-Eluting Coronary Stent System with the permanent polymer PROMUS Element Stent for the treatment of \u003Cem\u003Ede novo\u003C\/em\u003E atherosclerotic lesions.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003ETwo SYNERGY bioabsorbable stents were compared with the PROMUS Element permanent polymer stent. One SYNERGY stent had an everolimus dose and release profile that was similar to that of the PROMUS Element. The SYNERGY \u00bd Dose had half the dose of everolimus and a similar release profile to the PROMUS Element. Patients with \u003Cem\u003Ede novo\u003C\/em\u003E native coronary lesions (\u226428 mm in length, reference vessel diameter \u22652.5 mm and \u22643.5 mm, %DS \u0026gt;50) were randomized to receive the PROMUS Element (n=98), SYNERGY (n=94), or SYNERGY \u00bd Dose (n=99). The primary clinical endpoint was target lesion failure (TLF) at 30 days, defined as target vessel cardiac death, target vessel myocardial infarction (MI), or target lesion revascularization. The primary angiographic endpoint was in-stent late loss at 6 months. The study was designed to demonstrate that the SYNERGY stent was noninferior to the PROMUS Element.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EBoth SYNERGY and SYNERGY \u00bd Dose stents were noninferior to the PROMUS Element with respect to late loss at 6 months (0.10 vs 0.13 vs 0.15; p=0.19 and p=0.13, respectively, for the SYNERGY and SYNERGY \u00bd Dose stents compared with PROMUS). Similarly, at 30 days, the SYNERGY and SYNERGY \u00bd Dose stents were both noninferior compared with the PROMUS Element with respect to TLF (1.1% vs 3.1% vs 0%; p=0.49 and p=0.25, respectively).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EClinical events were infrequent (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E) and did not differ between stent types.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/12644\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/12644\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12644\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EClinical Events at 6 Months.\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-9\u0022\u003EThis study was limited by the small sample size, and therefore, the study lacked the power to detect differences in low-frequency clinical endpoints, such as stent thrombosis, death, and MI. This study population was a relatively low-risk cohort, limiting generalizability. Two future studies are planned that are powered to assess clinical event rates and optimal duration of DAPT.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EThe results of this trial show that the 2 dose formulations of the SYNERGY stent were noninferior to the PROMUS Element stent for both the primary clinical endpoint of TLF at 30 days and the primary angiographic endpoint of in-stent late loss at 6 months. Clinical events were low overall, with no stent thrombosis in any group. These results support the safety and potential efficacy of the novel, abluminal, bioabsorbable polymer SYNERGY everolimus-eluting stent for the treatment of patients with \u003Cem\u003Ede novo\u003C\/em\u003E coronary artery disease. Additional research is needed to evaluate clinical event rates and the potential for DAPT reduction with this novel stent.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/14\/9.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmvzp\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzmvzp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}