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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EClinical outcomes, safety, and recanalization rates using the Merci retriever embolectomy device are similar to those seen in previous prospective studies. In this study, investigators compared data from the Merci Registry with pooled data from the Mechanical Embolus Removal in Cerebral Ischemia [MERCI] and Multi MERCI trials to evaluate the clinical outcomes, safety, and recanalization rates of the Merci retriever embolectomy device in a \u201creal world\u201d setting.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Eischemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Einterventional techniques \u0026amp; devices neurology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EClinical outcomes, safety, and recanalization rates using the Merci retriever embolectomy device are similar to those seen in previous prospective studies. In this study by Jovin and colleagues, investigators compared data from the Merci Registry with pooled data from the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials to evaluate the clinical outcomes, safety, and recanalization rates of the Merci retriever embolectomy device in a \u201creal world\u201d setting.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe primary endpoint was revascularization, defined as Thrombolysis in Cerebral Infarction (TICI) score of 2a or higher. The secondary endpoint was clinical outcomes at 90 days. Outcomes were evaluated at 24 hours (determined by NIH Stroke Score [NIHSS] and symptomatic intracranial hemorrhage [sICH]), discharge (determined by NIHSS and modified Rankin Scores [mRS]), and 90 days (determined by mRS). A total of 625 patients with acute ischemic stroke, large vessel intracranial occlusion, and at least one pass with the Merci retriever were included in the primary analysis. Of the 625 patients, 20% were octogenarians.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EWhile both cohorts who were subjected to comparison presented with severe strokes, patients who were included in the pooled Merci\/Multi Merci (M\/MM) data had more severe strokes at presentation compared with those in the Merci Registry (mean NIHSS in the Mercy Registry 17.9 versus 19.6 in the M\/MM group, p\u0026lt;0.0001). There was no significant difference in comorbidities or occlusion location between the two data sets. The incidence of adjuvant pharmacological thrombolysis (ie, intravenous lytic or intra-arterial lytic) was higher in the Merci Registry than in M\/MM (p\u0026lt;0.0001).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe time from last seen at baseline to procedure onset (in hours) was higher in the Merci registry (5.72\u00b13.28) than in M\/MM (4.35\u00b11.76; p\u0026lt;0.001). However, no association was found between time to procedure and clinical outcome. The majority of procedures in the Merci registry occurred between 3 and 8 hours after symptom onset (73.7%). The rate of procedures that started 8 hours or more after symptom onset was higher in the Merci registry (14.1%) than in M\/MM (1.3%; p\u0026lt;0.001), highlighting a recent trend toward imaging rather than time-based selection for acute stroke interventions, which, in selected cases, enables expansion of the therapeutic time window beyond 8 hours. Overall, revascularization rates of TICI 2a and TICI 2b-3 were associated with lower mortality rates (32% and 28%, respectively; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E) and with significantly higher rates of favorable clinical outcomes in multivariate analyses (odds ratio 2.97, p\u0026lt; 0.0001)\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/1\/19\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Mortality Rates According to Revascularization (TICI) Score.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-858354560\u0022 data-figure-caption=\u0022Mortality Rates According to Revascularization (TICI) Score.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/1\/19\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/1\/19\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/1\/19\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11219\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EMortality Rates According to Revascularization (TICI) Score.\u003C\/p\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReproduced with permission from T. Jovin, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003ERecanalization rates were significantly better in the Merci registry (77%) versus M\/MM (65%). However, successful recanalization was defined differently in the two groups, based on TICI score in the Mercy Registry versus TIMI score in the M\/MM data. Modified Rankin Scores \u22642 at 90 days and 90-day mortality rates were not significantly different between the two groups. Intubated state during procedure was an adverse predictor of good clinical outcome (p=0.0004) and was associated with a higher risk of mortality (p=0.0141) at 90 days. In a multivariate analysis that looked at revascularized subjects only, baseline NIHSS, age, procedure duration, intubated state during procedures, intra-arterial lytic, and glucose \u2265140 mg\/dL were significant predictors of clinical outcome at 90 days.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003ETudor G. Jovin, MD, Presbyterian University Hospital, Pittsburgh, PA, pointed out two important trends that were identified during this study. First, in support of other multicenter studies that were presented at the International Stroke Conference 2010, intubated state during the procedure was shown to negatively affect clinical outcome throughout this analysis. Second, though time to procedure was not associated with better clinical outcome, procedure duration affected clinical outcome. The shorter the procedure duration, the higher the chance of a good outcome, said Dr. Jovin.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EResults of this large, prospective study of mechanical embolectomy with the MERCI device were similar to those found in previous studies with regard to clinical outcome, safety, and recanalization rates. These data confirm that successful recanalization is associated with better clinical outcome. This study also shed some light on the effect of intubation, procedure duration, and time to treatment on clinical outcome. However, this analysis was based on nonrandomized, self-reported data in the absence of a control. Therefore, efficacy of this treatment approach compared with standard medical therapy was not addressed by this study, and further randomized controlled studies are warranted.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/1\/19.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmua1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmua1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}