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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EEpidemiological studies have documented a high prevalence of comorbid conditions among patients who have chronic obstructive pulmonary disease (COPD), including hypertension, ischemic heart disease, hypercholesterolemia, diabetes, and anxiety and depression [Barr RG et al. \u003Cem\u003EAm J Med\u003C\/em\u003E 2009; Carrasco-Garrido P et al. \u003Cem\u003EBMC Pulm Med\u003C\/em\u003E 2009; Finkelstein J et al. \u003Cem\u003EInt J COPD\u003C\/em\u003E 2009]. The epidemiological data underscore the need to know whether clinical trial results have come from studies that adequately represent the comorbidities of COPD patients.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Echronic obstructive pulmonary disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Epulmonary clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EEpidemiological studies have documented a high prevalence of comorbid conditions among patients who have chronic obstructive pulmonary disease (COPD), including hypertension, ischemic heart disease, hypercholesterolemia, diabetes, and anxiety and depression (Barr RG et al. \u003Cem\u003EAm J Med\u003C\/em\u003E 2009; Carrasco-Garrido P et al. \u003Cem\u003EBMC Pulm Med\u003C\/em\u003E 2009; Finkelstein J et al. \u003Cem\u003EInt J COPD\u003C\/em\u003E 2009). The epidemiological data underscore the need to know whether clinical trial results have come from studies that adequately represent the comorbidities of COPD patients.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003ETo examine comorbidities in clinical trials of tiotropium, Marc Miravitlles, MD, Ciber de Enfermedades Respiratorias, Barcelona, Spain, and colleagues analyzed data from 26 placebo-controlled clinical trials that were at least 4 weeks in duration. Baseline evaluation included documentation of patients\u0027 concomitant diseases and relevant medical history of the previous 5 years.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe analysis comprised 17,014 patients with COPD whose mean age was 64.6 years. The data showed that 76% of the patients were men, 84.4% was Caucasian, and baseline mean forced expiratory volume in one second (FEV\u003Csub\u003E1\u003C\/sub\u003E) was 41% of predicted.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EInformation on baseline comorbid conditions was available for 15,375 patients. Overall, 90.4% of the patients had concomitant diseases at baseline.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EThe most frequently cited categories of comorbid conditions were vascular disorders (44.0%), musculoskeletal and connective tissue disorders (35.2%), gastrointestinal disorders (32.6%), metabolism and nutrition disorders (28.8%), dyslipidemia (16.7%), diabetes (9.8%), and anxiety or depression (13.7%).\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EBecause COPD and cardiovascular conditions frequently occur together, the investigators analyzed the data for specific references to individual disorders within the broader category of cardiovascular disease. They found that 38.7% of patients had hypertension, 15.6% had conditions that were suggestive of ischemic heart disease, and 16.7% had hypercholesterolemia or hyperlipidemia. With the exception of lipid and cholesterol abnormalities, the comorbidities of patients in the tiotropium clinical trials had prevalences that were similar to those of previous epidemiological studies, investigators concluded. Epidemiological data have generally shown higher rates of hypercholesterolemia or hyperlipidemia among patients with COPD.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/3\/9.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmsr1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}