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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EA study of two standard therapies for post-traumatic stress disorder (PTSD) showed that outcomes are better when patient preference is taken into account when prescribing treatment. While treatment with a selective serotonin reuptake inhibitor (SSRI) and treatment via prolonged exposure were both effective in the study, the best outcomes were observed in patients who were actively involved in treatment selection.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EAnxiety Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychopharmacology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EA study of two standard therapies for post-traumatic stress disorder (PTSD) showed that outcomes are better when patient preference is taken into account when prescribing treatment.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EWhile treatment with a selective serotonin reuptake inhibitor (SSRI) and treatment via prolonged exposure (PE) were both effective in the study, the best outcomes were observed in patients who were actively involved in treatment selection. The study by Nora C Feeny, PhD, Case Western Reserve University, Cleveland, OH, is the first direct comparison of an SSRI and exposure-based treatment, and it also highlights the need to consider the patient\u0027s preference when prescribing treatment.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EBoth sertraline (SER) and PE are effective treatments for PTSD, however, they represent very different options. With PE, patients are encouraged to directly approach the trauma memory and trauma-related fears. With SER, this level of engagement with trauma-related stimuli is not necessary.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EDr. Feeny and colleagues sought to understand how the two approaches compare in efficacy for chronic PTSD, and how patient preference for one form over the other may influence the treatment effect.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe study was a randomized preference trial. All subjects viewed a video in which the two treatments were described in a non-biased manner. Patients were then randomly assigned to be further randomized to one treatment or the other, or were permitted to select their treatment option. Patients entering the randomization arm were assigned to PE or SER without consideration of preference (though some patients inadvertently received their preferred treatment). Patients assigned to the \u201cchoice\u201d arm were allowed to select their treatment, permitting investigators to determine how patient preference impacts treatment effect.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EOut of 426 patients with a DSM-IV primary diagnosis of chronic PTSD, 200 were ultimately allocated to either the randomization arm or the choice arm.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThe study population was primarily female with a history of adult sexual assault (31%), adult non-sexual assault (22.5%), or childhood assault (24%). Only 2.5% of patients\u0027 PTSD was a result of a combat related incident. The median time since trauma exposure was 12 years, and the average participant reported 9 additional trauma types aside from the target trauma. Nearly all had received prior psychiatric treatment.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003E\u201cThis was a large, diverse and clinically complex sample characterized by longstanding PTSD, extensive trauma exposure, high levels of previous treatment-seeking and substantial comorbidity,\u201d Dr. Fenny noted.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EPsychopathology and function scales included the Structured Clinical Interview for the DSM-IV (SCID-IV), the PTSD Symptom Scale (PSS-I), the Hamilton Ratings Scale for Depression (HRSD-24), the PTSD Symptom Scale\u2014Self-Report (PSS-SR), the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory (STAI), and the Sheehan Disability Scale (SDS). SER was administered in a flexible dosing schedule (50\u2013200 mg) under a standardized titration algorithm. Patients were treated in 10 weekly 30-minute sessions.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EThe PE arm received education about common reactions to trauma, breathing retraining, prolonged repeated exposure to the trauma memory, and repeated \u003Cem\u003Ein vivo\u003C\/em\u003E exposure to situations they were avoiding. Treatment occurred in 10 weekly sessions of 90 to 120 minutes.\u003C\/p\u003E\u003Cp id=\u0022p-12\u0022\u003E\u201cOverall, both PE and SER showed good efficacy,\u201d Dr. Feeny reported. \u201cGlobally, almost all the treatment effects for both arms were large. PE may have had a slight advantage in terms of magnitude of change and loss of the PTSD diagnosis at 10 weeks, which is generally consistent with the published literature.\u201d\u003C\/p\u003E\u003Cp id=\u0022p-13\u0022\u003EThe changes from baseline in key measures of PTSD are shown in \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E. Treatment effects of 0.8 and higher are considered to have a large impact clinically.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/11269\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/11269\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11269\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-14\u0022 class=\u0022first-child\u0022\u003EPre- to Post-Treatment Effect Sizes (ITT).\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-15\u0022\u003ESince this was an intention-to-treat analysis, which included patients who did not complete treatment, Dr. Feeny believes these results underestimate actual treatment impact.\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003E\u201cImportantly, there were clear effects on PTSD outcome of being randomized to the choice arm,\u201d she noted. \u201cPatients who had no choice in their treatment had more diminished effects.\u201d\u003C\/p\u003E\u003Cp id=\u0022p-17\u0022\u003EThe most prominent effects were seen when there was a discrepancy between the treatment assignment and the patient\u0027s preference. Among patients who did not receive their preferred treatment 59% continued to experience PTSD, compared to 29% in non-discrepant cases. They also suffered more severe PTSD as well as depression and anxiety, though some of this effect may be due to lack of treatment adherence.\u003C\/p\u003E\u003Cp id=\u0022p-18\u0022\u003EThe study found evidence of lower SER dosage at the end of the study, less adherence to PE homework and lower treatment completion rates among the discrepant population. Mean SER dose was 144 mg\/day for patients who chose SER compared with 62 mg\/day for those who preferred PE but received SER (p\u0026lt;0.001).\u003C\/p\u003E\u003Cp id=\u0022p-19\u0022\u003EIn addition, the number of sessions completed was 7.69 for patients lacking discrepancy and 5.14 for those with discrepancy (p\u0026lt;0.001), and treatment completion rates were 73% and 49%, respectively (p=0.002).\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/4\/16.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmsc1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzmsc1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}