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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EMilnacipran may be an effective treatment for the fatigue that is associated with fibromyalgia (FM). FM is a chronic disorder with symptoms, including musculoskeletal pain and allodynia, as well as debilitating fatigue. Milnacipran is a dual reuptake inhibitor of serotonin and norepinephrine that is used for the treatment of FM. This article discusses an evaluation the effect of milnacipran on fatigue in patients with FM (as determined by American College of Rheumatology criteria) in a pooled analysis of three Phase III trials.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EPsychiatry Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EFibromyalgia\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EMilnacipran may be an effective treatment for the fatigue that is associated with fibromyalgia (FM). FM is a chronic disorder with symptoms, including musculoskeletal pain and allodynia, as well as debilitating fatigue. Milnacipran is a dual reuptake inhibitor of serotonin and norepinephrine that is used for the treatment of FM. Allan Spera, MD, Forest Pharmaceuticals, Jersey City, NJ, and colleagues evaluated the effect of milnacipran on fatigue in patients with FM (as determined by American College of Rheumatology criteria) in a pooled analysis of three Phase III trials.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn these three trials, patients were randomized to receive milnacipran 100 mg daily (n=1139), milnacipran 200 mg daily (n=837), or placebo (n=1133) for 12 weeks following a dose escalation phase. The mean age was 49 years, and the majority of patients (\u223c94%) was female. The three groups were well matched at baseline. Patients with severe psychiatric illness or medical condition or who were experiencing a current major depressive episode (determined by Mini-International Neuropsychiatric Interview [MINI] and Beck Depression Inventory \u22654) were excluded from participation in the study. Efficacy measures were change from baseline on Multidimensional Fatigue Inventory (MFI) total and subscale scores and Fibromyalgia Impact Questionnaire (FIQ) fatigue-related questions 6 and 7 (question 6: \u201cHow tired have you been?\u201d and question 7: \u201cHow have you felt when you get up in the morning?\u201d) at 3 months.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients in both milnacipran treatment arms demonstrated significant improvement in MFI total score and FIQ items 6 and 7 compared with placebo at 3 months (p\u0026lt;0.01). There was a significant reduction in fatigue at all study visits among patients who were taking milnacipran (p\u0026lt;0.01 for both doses). Significant improvement in all MFI subscale scores was observed in those who were treated with milnacipran 200 mg daily compared with placebo (p\u0026lt;0.05). Those who were treated with milnacipran 100 mg daily demonstrated significant improvement in the general fatigue, physical fatigue, and reduced motivation subscale categories compared with placebo (p\u0026lt;0.05).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOverall, treatment with milnacipran resulted in favorable outcomes that were related to fatigue in patients with FM. This benefit was observed in the MFI total scores and FIQ (questions 6 and 7) scores, as well as several of the MFI fatigue-related subscale categories. A modest correlation was found between MFI total score and pain and Patient Global Impression of Change (PGIC) scores at endpoint. However, similar correlations were found among the placebo-treated patients. While milnacipran is currently being used for the treatment of pain that is associated with FM, it may also be an effective treatment for fatigue in patients with FM. Further studies that focus on the fatigue aspect of FM are needed to establish the efficacy of milnacipran for the treatment of fatigue symptoms in patients with FM.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/4\/14.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmsc1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}