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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ECaffeine ingestion prior to exercise may reduce hypoglycemic episodes and slow the decline in blood glucose during exercise in patients with type 1 diabetes mellitus. This article discusses findings from a small study that investigated the physiological impact of caffeine ingestion prior to exercise.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHyperglycemia\/Hypoglycemia\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ECaffeine ingestion prior to exercise may reduce hypoglycemic episodes and slow the decline in blood glucose during exercise in patients with type 1 diabetes mellitus (T1DM). Ian W. Gallen, MD, Wycombe Hospital, Buckinghamshire, United Kingdom, presented findings from a small study that investigated the physiological impact of caffeine ingestion prior to exercise.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThis study evaluated 5 patients with T1DM (4 males and 1 female) who were on multiple daily injection therapy. The mean age was 38.2 years, and the mean body mass index was 27.32. Study Day 1 consisted of workload assessment, as determined by maximum oxygen consumption (VO\u003Csub\u003E2\u003C\/sub\u003E max). Patients were randomized to receive either caffeine 5 mg\/kg or placebo 2 hours postprandially\/after glargine-aspart injection with rest for 30 minutes prior to exercise. Subjects exercised on a cycle ergometer for 10 minutes at 50% VO\u003Csub\u003E2\u003C\/sub\u003E max, increasing to 70% VO\u003Csub\u003E2\u003C\/sub\u003E max for 30 minutes. After a total of 40 minutes of exercise, patients rested for 30 minutes. Arterialized blood glucose and lactate were measured every 10 minutes, gas exchange was measured continuously, and respiratory exchange rate (RER) was calculated. At least 1 week later, an identical exercise protocol was administered, but the patients received the opposite treatment regimen (those who previously received caffeine were given placebo and vice versa).\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EBlood glucose remained similar to baseline levels throughout the duration of the exercise and into the resting phase of the program in those who received caffeine. None of the subjects in the caffeine group required oral glucose. Subjects who were taking caffeine demonstrated significantly higher blood glucose levels compared with placebo after exercising at 70% VO\u003Csub\u003E2\u003C\/sub\u003E max for 10 minutes (p=0.014), after exercising at 70% for 30 minutes (p=0.032), and after 30 minutes of postexercise rest (p=0.01). Blood glucose levels began to fall at the start of exercise in those who received placebo, and this rapid decline continued throughout the exercise program. Oral glucose (20 g) was administered to 2 of the patients in the placebo group in order to avoid a hypoglycemic event.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ELactate and RER measurements remained relatively consistent throughout the exercise program in those who received caffeine. Caffeine did not appear to alter RER or increase lactate levels, which suggests that caffeine does not alter substrate oxidation. These findings also suggest that caffeine may augment endogenous glucose production and oxidation when coupled with exercise.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ECaffeine may be a useful tool in the prevention of hypoglycemic events during exercise in patients with T1DM. However, larger studies are needed to establish the safety and efficacy of such an approach.\u003C\/p\u003E\u003Cdiv class=\u0022boxed-text\u0022 id=\u0022boxed-text-1\u0022\u003E\u003Cbr\/\u003E\u003Cdiv class=\u0022graphic\u0022 id=\u0022graphic-1\u0022\u003E\u003Cdiv class=\u0022graphic-inline anchor\u0022\u003E\u003Cimg class=\u0022highwire-embed\u0022 alt=\u0022Embedded Image\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/highwire\/spmdc\/10\/6\/26\/embed\/graphic-1.gif\u0022\/\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EPlease help us improve \u003Cem\u003EMD Conference Express\u003C\/em\u003E\u00ae by taking our survey at: \u003Ca href=\u0022http:\/\/www.surveymonkey.com\/s\/mdce_ADA2010\u0022\u003Ewww.surveymonkey.com\/s\/mdce_ADA2010\u003C\/a\u003E\n         \u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003E\n            \u003Cstrong\u003Eand receive complimentary access to the 2010 American College of Cardiology report.\u003C\/strong\u003E\n         \u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/6\/26.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmrld\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}