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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe 3-year extension of the Candesartan Antihypertensive Survival Evaluation in Japan [CASE-J] Study demonstrated comparable efficacy of the angiotensin receptor blocker candesartan and the calcium channel blocker amlodipine on the incidence of cardiovascular events in high-risk hypertensive Japanese patients. As observed in the earlier phase of the study, cadesartan exhibited sustained superiority over amlodipine with regards to reduction in new-onset diabetes throughout the 3-year extended follow up.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe 3-year extension of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Study demonstrated comparable efficacy of the angiotensin receptor blocker candesartan and the calcium channel blocker amlodipine on the incidence of cardiovascular (CV) events in high-risk hypertensive Japanese patients. As observed in the earlier phase of the study, cadesartan exhibited sustained superiority over amlodipine with regards to reduction in new-onset diabetes throughout the 3-year extended follow up. Kazuwa Nakao, MD, Kyoto University, Kyoto, Japan, presented findings from the CASE-J extended follow-up study.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe Case-J Extension included 2232 hypertensive patients from the original trial who were randomized to either candesartan (n=1140) or amlodipine (n=1092). The two groups were characteristically well-matched at baseline with a mean systolic blood pressure (SBP) of 163 mm Hg and a mean diastolic blood pressure (DBP) of 92 mm Hg. The mean age of study participants was 64 years and the mean body mass index (BMI) was \u223c24.5. The two groups also had similar comorbidities and risk factors at baseline. The primary composite endpoint was the incidence of CV mortality and morbidity, defined as sudden death and CV, cardiac, renal, and vascular events. The secondary endpoints included the incidence of all-cause death, CV death, and new-onset diabetes.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EBP was well-controlled in both treatment groups throughout the duration of the early trial and this benefit was maintained over the extended course of follow-up. There was no significant difference in the incidence of CV events between the two groups. Analysis of the single primary endpoint components (sudden death, CV events, cardiac events, renal events, and vascular events) found no significant difference between cadesartan and amlodipine treatment. The incidence of all-cause death was also comparable for both treatment groups.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ETreatment with candesartan significantly reduced the incidence of new-onset diabetes compared with amlodipine during the original study arm (p=0.031) and this benefit was demonstrated further in the extension arm of the study. A 29% relative risk reduction of new-onset diabetes was observed in the candesartan group compared with amlodipine (HR, 0.71; 95% CI, 0.51 to 1.00; p=0.0495; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). There also appeared to be an interaction between BMI and new-onset diabetes (interaction p=0.187). Increases in risk reduction correlated with increased BMI, particularly in patients with BMI \u2265 27.5 (p=0.049; \u003Ca id=\u0022xref-fig-1-2\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/12.1\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Relationship Between New-onset Diabetes and BMI.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-318286934\u0022 data-figure-caption=\u0022Relationship Between New-onset Diabetes and BMI.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/12.1\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/12.1\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/12.1\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11307\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003ERelationship Between New-onset Diabetes and BMI.\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EFindings from the CASE-J Extension study provided valuable long-term data regarding the efficacy of candesartan and amlodipine on the incidence of CV events and new-onset diabetes in high-risk hypertensive patients. While results were comparable for both treatments concerning CV events, the incidence of new-onset diabetes was significantly reduced with candesartan compared with amlodipine and this benefit was sustained over time.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/5\/12.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmqwd\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmqwd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}