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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article discusses findings from this phase III, multicenter, parallel-group, double-blind, randomized placebo-and active-controlled trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00696241\u0026amp;atom=%2Fspmdc%2F10%2F5%2F11.atom\u0022\u003ENCT00696241\u003C\/a\u003E]. The purpose of this study was to compare the BP lowering effects of azilsartan medoxomil with olmesartan medoxomil and placebo over a period of 6 weeks in patients with primary hypertension.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EIn a recent study comparing azilsartan medoxomil (AZL-M) with olmesartan medoxomil (OLM-M) and placebo, AZL-M therapy was found to be safe and effective in patients with primary hypertension. Angiotensin receptor blockers (ARB) such as OLM-M are thought to be better tolerated than other classes of antihypertensives. However, many patients continue to experience inadequate blood pressure (BP) control despite medical therapy. Therefore, more therapeutic options are being investigated in the hopes of providing more reliable BP control. OLM-M was chosen as a comparative ARB due to its similarity to AZL-M with regards to its mechanism of action.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EGeorge L. Bakris, MD, University of Chicago Medical Center, Chicago, Illinois, USA, presented findings from this phase III, multicenter, parallel-group, double-blind, randomized placebo-and active-controlled trial (\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00696241\u0026amp;atom=%2Fspmdc%2F10%2F5%2F11.atom\u0022\u003ENCT00696241\u003C\/a\u003E). The purpose of this study was to compare the BP lowering effects of AZL-M with OLM-M and placebo over a period of 6 weeks in patients with primary hypertension.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 1275 patients were randomized to receive AZL-M 20 mg daily (n=283), AZL-M 40 mg daily (n=283), AZL-M 80 mg daily (n=285), OLM-M 40 mg daily (n=282) or placebo (n=142) and BP was evaluated using ambulatory BP monitoring (ABPM) and clinic BP measurement. Patients with trough sitting clinic diastolic BP \u0026gt;114 mm Hg, history of a major cardiovascular event, secondary hypertension, hyperkalemia, renal artery stenosis, or Type 1\/poorly controlled diabetes were excluded from participation in the study. The groups were well-matched at baseline with regards to demographics and BP readings.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe primary endpoint was change in 24-hour mean systolic BP (SBP) from baseline to Week 6, as determined by ABPM. The secondary efficacy endpoints included change from baseline to Week 6 in trough sitting clinic SBP, 24-hour mean sitting diastolic BP (DBP) according to ABPM, and other ABPM parameters, such as mean trough BP at 22 to 24 hours post-dosing. Secondary safety endpoints included adverse events and laboratory data.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ETreatment with all doses of AZL-M resulted in significantly lower 24-hour mean SBP compared with placebo at Week 6 (p\u0026lt;0.001 for all doses). This was also the case with 24-hour mean DBP in AZL-M patients versus placebo (0\u0026lt;0.001 for all doses). Patients taking AZL-M 80 mg had significantly reduced 24-hour mean SBP compared with OLM-M 40 mg (p=0.038; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). The AZL-M 80 mg group also demonstrated significant improvement in trough sitting clinic SBP and DBP at Week 6 compared with OLM-M 40 mg (p=0.043 and p=0.044, respectively).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/11\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u002224-Hour Mean SBP by ABPM.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-2138993276\u0022 data-figure-caption=\u002224-Hour Mean SBP by ABPM.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/11\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/11\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/5\/11\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11304\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003E24-Hour Mean SBP by ABPM.\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-8\u0022\u003ESerious adverse events occurred in 2.1% of patients in the placebo group, 2.8% in the AZL-M 20 mg group, 0.4% in the AZL-M 80 mg group, and 0.7% in the OLM-M group. No serious adverse events were reported in the AZL-M 40 mg group. A total of 30 patients discontinued treatment due to adverse events (6 in placebo, 11 in AZL-M 20 mg, 3 in AZL-M 40 mg, 6 in AZL-M 80 mg, and 4 in OLM-M 40 mg group). One death did occur in the AZL-M 20 mg group. Overall, the safety profiles of all AZL-M doses were similar to that of OLM-M and placebo.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EThese findings demonstrate that AZL-M is safe and effective for the treatment of primary hypertension. It is important to note that AZL-M is not currently licensed for the treatment hypertension. However, these results are quite promising and warrant further investigation.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/5\/11.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmqwd\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmqwd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}