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{\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022highwire\u0022:{\u0022markup\u0022:[{\u0022requested\u0022:\u0022full-text\u0022,\u0022variant\u0022:\u0022full-text\u0022,\u0022view\u0022:\u0022full\u0022,\u0022pisa\u0022:\u0022spmdc;10\\\/7\\\/29-a\u0022},{\u0022requested\u0022:\u0022long\u0022,\u0022variant\u0022:\u0022full-text\u0022,\u0022view\u0022:\u0022full\u0022,\u0022pisa\u0022:\u0022spmdc;10\\\/7\\\/29-a\u0022}],\u0022ac\u0022:{\u0022spmdc;10\\\/7\\\/29-a\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022spmdc;10\\\/7\\\/29-a\u0022,\u0022atom_uri\u0022:\u0022\u0022,\u0022jcode\u0022:\u0022spmdc\u0022}}},\u0022googleanalytics\u0022:{\u0022trackOutbound\u0022:1,\u0022trackMailto\u0022:1,\u0022trackDownload\u0022:1,\u0022trackDownloadExtensions\u0022:\u00227z|aac|arc|arj|asf|asx|avi|bin|csv|doc(x|m)?|dot(x|m)?|exe|flv|gif|gz|gzip|hqx|jar|jpe?g|js|mp(2|3|4|e?g)|mov(ie)?|msi|msp|pdf|phps|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|sea|sit|tar|tgz|torrent|txt|wav|wma|wmv|wpd|xls(x|m|b)?|xlt(x|m)|xlam|xml|z|zip\u0022,\u0022trackUrlFragments\u0022:1},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u0022sites\\\/all\\\/libraries\\\/cluetip\\\/jquery.cluetip.js\u0022:1,\u0022sites\\\/all\\\/libraries\\\/cluetip\\\/lib\\\/jquery.hoverIntent.js\u0022:1,\u0022sites\\\/all\\\/libraries\\\/cluetip\\\/lib\\\/jquery.bgiframe.min.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/highwire_markup_process\\\/js\\\/highwire_at_symbol.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/highwire_markup_process\\\/js\\\/highwire_article_reference_popup.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/google_analytics\\\/googleanalytics.js\u0022:1,\u00220\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\n\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cp id=\u0022p-1\u0022\u003EThere are many factors that increase the risk of developing coronary artery disease (CAD), including hypertension, dyslipidemia, inflammation, health behaviors, and genetics. Robert Chilton, DO, FACC, Professor of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA, highlighted recent evidence concerning CAD treatment and described the clinical shift in therapeutic concentration from vulnerable plaque to genomics and metabolomics to improve drug risk benefit.\u003C\/p\u003E\u003Cp id=\u0022p-2\u0022\u003ERecent studies have revealed an association between certain genetic phenotypes and CAD risk. In a meta-analysis by Schunkert and colleagues, genetic variants at chromosome 9p21.3 were associated with a 30% increase in CAD per copy of the 9p21.3 risk allele for heterozygote mutation [Schunkert H et al. \u003Cem\u003ECirculation\u003C\/em\u003E 2008]. This study supported previous findings that mutations within this genetic locus conveyed a higher risk of CAD [Nilesh J et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2007]. Additionally, a Trp719Arg polymorphism within the KIF6 gene, which encodes for a kinesin, also predicts development of CAD [Iakoubova OA et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E 2008]. These results begin to elucidate the role of genetics in the risk of developing CAD and may prove to be useful predictive markers in the future.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn a population-based study, reductions in short-term fatality rates from myocardial infarction (MI) between 1999 and 2008 were associated, in part, with the use of effective therapeutics, such as statins, renin angiotensin aldosterone system (RAAS) blockers, and \u03b2-blockers [Yeh RW et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2010]. However, genes also play a role in treatment response, and more individualized strategies may be warranted, based on varying gene polymorphisms and therapeutic interactions. In the PROVE IT-TIMI 22 trial, carriers of 719Arg demonstrated significantly greater benefit from intensive statin therapy compared with noncarriers (41% relative risk reduction [RRR] in death\/MI; p=0.018) [Iakoubova OA et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E 2008]. Similar evaluations that were performed in the CARE and WOSCOPS trials also showed that pravastatin therapy effectively reduced the risk of coronary events in KIF6 719Arg carriers, with a 54% RRR in coronary heart disease and a 41% RRR in acute MI [Iakoubova OA et al. \u003Cem\u003EJ Am Coll Cardiol\u003C\/em\u003E 2008]. Alternatively, variants that were identified within SLCO1B1 (rs4363657) were strongly associated with an increased risk of statin-induced myopathy [SEARCH Collaborative Group. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2008]. Thus, the need to consider genetics when determining an appropriate treatment strategy has become more apparent.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThere has been increasing evidence of interactions between gene polymorphisms and therapies that are associated with variability in coronary risk. Pharmacogenomics and variable therapeutic responses have altered views on treatment approaches and may lead to more emphasis on genetic predictors of risk and therapeutic response moving forward. While previous strategies have focused on factors, such as inflammation, lipids, glucose, and other risk measurements, future approaches may incorporate additional factors, such as individual risk profile, genomics, and biomarkers.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmqe1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}