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xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ETreatment with rivaroxaban provided a simple, safe, and effective alternative to standard anticoagulation therapy for patients with deep vein thrombosis, according to findings from the phase III Oral Direct Factor Xa Inhibitor Rivaroxaban In Patients With Acute Symptomatic Deep-Vein Thrombosis Without Symptomatic Pulmonary Embolism [Einstein-DVT; NCT 00440193].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EThrombotic Disorders\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ETreatment with rivaroxaban provided a simple, safe, and effective alternative to standard anticoagulation therapy for patients with deep vein thrombosis (DVT), according to findings from the phase III Oral Direct Factor Xa Inhibitor Rivaroxaban In Patients With Acute Symptomatic Deep-Vein Thrombosis Without Symptomatic Pulmonary Embolism (Einstein-DVT; NCT 00440193). Harry R. Buller, MD, PhD, Academic Medical Center, Amsterdam, The Netherlands, presented findings from EINSTEIN DVT.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ERivaroxaban is an investigational oral factor Xa inhibitor. For patients who require anticoagulation, single-agent rivaroxaban presents an attractive alternative to standard combination therapy with low-molecular-weight heparin and warfarin, which requires subcutaneous injections, dietary restrictions, and close monitoring to confirm clotting time. One potential limitation of rivaroxaban is the lack of antidote to rapidly reverse its anticoagulation activity. By comparison, the effects of warfarin can be reversed with the administration of vitamin K.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe open-label EINSTEIN DVT trial included 3449 patients with symptomatic DVT and without symptomatic pulmonary embolism (PE). Patients were randomly assigned to treatment with rivaroxaban 15 mg twice daily for 3 weeks, followed by a 20-mg maintenance dose (n=1731), or body weight-adjusted subcutaneous enoxaparin 1 mg\/kg twice daily for at least 5 days, followed by warfarin (n=1718). Anticoagulation treatment continued for 3, 6, or 12 months at the discretion of the treating physician. The primary endpoint was symptomatic venous thromboembolism (VTE), which was defined as a composite of recurrent DVT, nonfatal PE, and fatal PE.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ERivaroxaban reduced the risk of recurrent VTE compared with standard therapy (2.1% vs 2.0%), meeting the criteria for noninferiority (p\u0026lt;0.0001) and approaching statistical significance for superiority (p=0.076). Among individual efficacy outcomes, rivaroxaban reduced the risk of recurrent DVT by half compared with enoxaparin and warfarin (0.8% vs 1.6%). Other outcomes were comparable in the rivaroxaban and standard therapy groups, including nonfatal PE (1.2% vs 1.0%) and fatal PE (0.2% vs 0.3%).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe net clinical benefit, which accounted for symptomatic VTE plus major bleeding, also favored rivaroxaban over enoxaparin and warfarin (HR, 0.67; 95% CI, 0.47 to 0.95). An analysis of safety outcomes showed similar rates of bleeding, including major and clinically relevant nonmajor bleeding, for rivaroxaban compared with standard therapy (8.1% vs 8.1%; p=0.77). Rivaroxaban was not associated with liver toxicity, a safety concern with other factor Xa inhibitors.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe EISTEIN DVT trial supports the use of rivaroxaban as a simplified approach for treating DVT and preventing recurrent VTE, Prof. Buller concluded. A companion trial, EINSTEIN PE, is currently underway to compare the efficacy and safety of rivaroxaban versus enoxaparin and warfarin in patients with symptomatic PE.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/8\/17.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmp1p\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}