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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article discusses data that addressed the issue of whether arterial stiffness was prospectively associated with a higher left ventricular (LV) mass and worse LV diastolic function (indicated by increasing left atrial volume index) and whether this differed in individuals with or without type 2 diabetes mellitus.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHeart Failure\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EIndividuals with diabetes are more likely to develop congestive heart failure (HF), particularly left-sided HF, than those without diabetes, but the underlying mechanisms remain controversial [Nichols GA et al. \u003Cem\u003EDiabetes Care\u003C\/em\u003E 2004]. Arterial stiffness, which is more common in type 2 diabetes mellitus (T2DM), has been suggested as a potential cause of HF, while left ventricular (LV) mass has been shown to be a predictor [Stehouwer CD et al. \u003Cem\u003EDiabetologia\u003C\/em\u003E 2008; de Simone G et al. \u003Cem\u003EEur Heart J\u003C\/em\u003E 2008]. Katja van den Hurk, PhD candidate, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands, presented data that addressed the issue of whether arterial stiffness was prospectively associated with a higher LV mass and worse LV diastolic function (indicated by increasing left atrial volume index [LAVI]) and whether this differed in individuals with or without T2DM.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThese results were from an 8-year follow-up to the Hoorn Study, a population-based cohort study of diabetes and diabetes complications that began in 1989 [Henry RM et al. \u003Cem\u003EDiabetes Care\u003C\/em\u003E 2004]. Echocardiography and arterial ultrasonography were performed in 2000 and again in 2008. Linear regression analyses were performed to investigate associations between baseline carotid, brachial, and femoral artery distensibility coefficients (DCs, arterial stiffness) with LV mass index (LVMI, g\/m\u003Csup\u003E27\u003C\/sup\u003E) and LAVI (mL\/m\u003Csup\u003E2\u003C\/sup\u003E). The results were adjusted for age, gender, and mean arterial pressure (MAP). Individuals with moderate or severe mitral or aortic valve disease, or tachycardia (heart rate \u0026gt;90 beats per minute) were excluded.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EOf the 796 individuals for whom baseline echocardiograms were available, 394 were included in the present analysis. Subjects with T2DM (n=128; 32%) were older, had a higher LAVI and blood pressure, and stiffer arteries (lower arterial DCs) at baseline compared with those without T2DM. After adjusting for age and gender, more arterial stiffness at baseline was significantly (p\u0026lt;0.05) associated with higher LVMI and LAVI. Additional adjustment for baseline MAP showed that blood pressure only partly explained these associations.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ESubjects with T2DM have a significantly (p\u0026lt;0.05) higher LVMI and LAVI [van den Hurk et al. \u003Cem\u003EEur J Heart Fail.\u003C\/em\u003E 2010]. However, associations between arterial stiffness and LVMI or LAVI were not different for individuals with or without T2DM (p for interaction \u0026gt;0.10). Adjustments for HbA1C, heart rate, LVMI, systolic blood pressure, or use of antihypertensive medication did not change the results.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EArterial stiffness was prospectively associated with worse LV diastolic function, regardless of T2DM. However, individuals with T2DM commonly have stiffer arteries compared with those without T2DM, suggesting that arterial stiffening might be one of the causes of worse LV diastolic function in T2DM.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/9\/23.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmnw3\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}