RT Journal Article SR Electronic A1 Vinall, Maria T1 No Significant Benefit with Rosiglitazone in Preventing Progression of Atherosclerosis in Diabetic Patients with a History of Cardiovascular Disease JF MD Conference Express YR 2009 FD SAGE Publications VO 8 IS 8 SP 21 OP 22 DO 10.1177/155989770900800813 UL http://mdc.sagepub.com/content/8/8/21.abstract AB Thiazolidinediones, such as rosiglitazone, have been shown to increase insulin sensitivity and reduce other cardiovascular risk factors but increase fluid retention and the risk of heart failure. This article discusses results of the Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in Diabetes Patients with Cardiovascular History [APPROACH; NCT00116831] trial.