PT - JOURNAL ARTICLE AU - Vinall, Phil ED - Broderick, Joseph P. TI - The Physiologic Time Window in Acute Stroke DP - 2009 Apr 01 TA - MD Conference Express PG - 6--8 VI - 9 IP - 1 4099 - http://mdc.sagepub.com/content/9/1/6.short 4100 - http://mdc.sagepub.com/content/9/1/6.full AB - The most important treatment variable for a successful functional outcome following ischemic stroke is time to thrombolysis treatment. Recent evidence suggests that although earlier treatment leads to a better outcome, the treatment opportunity window is not fixed. This article discusses recent clinical trials that defined the optimal time window to maximize the effectiveness of reperfusion therapy in acute stroke.