RT Journal Article SR Electronic A1 Vinall, Phil T1 The Physiologic Time Window in Acute Stroke JF MD Conference Express YR 2009 FD SAGE Publications VO 9 IS 1 SP 6 OP 8 DO 10.1177/155989770901001 UL http://mdc.sagepub.com/content/9/1/6.abstract AB The most important treatment variable for a successful functional outcome following ischemic stroke is time to thrombolysis treatment. Recent evidence suggests that although earlier treatment leads to a better outcome, the treatment opportunity window is not fixed. This article discusses recent clinical trials that defined the optimal time window to maximize the effectiveness of reperfusion therapy in acute stroke.