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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EResults of a subgroup analysis from the JUPITER trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00239681\u0026amp;atom=%2Fspmdc%2F9%2F4%2F22.atom\u0022\u003ENCT00239681\u003C\/a\u003E] showed a significant reduction in major cardiovascular (CV) events in older, apparently healthy individuals who were treated with rosuvastatin compared with placebo.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ELipid Disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPrevention \u0026amp; Screening Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EResults of a subgroup analysis from the JUPITER trial (\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00239681\u0026amp;atom=%2Fspmdc%2F9%2F4%2F22.atom\u0022\u003ENCT00239681\u003C\/a\u003E), presented by Robert Glynn, MD, PhD, Brigham and Women\u0027s Hospital, Boston, MA, showed a significant reduction in major cardiovascular (CV) events in older, apparently healthy individuals who were treated with rosuvastatin compared with placebo.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe JUPITER study comprised 17,802 apparently healthy men aged \u226550 years and women aged \u226560 years with LDL \u0026lt;130 mg\/dL who were at increased vascular risk due to elevated high-sensitivity C-reactive protein (hsCRP; \u22652 mg\/L). The primary endpoint of the study was major CV events, which were defined as the combined risk of myocardial infarction (MI), stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes. JUPITER was stopped early after a median follow-up of 1.9 years, on the basis of overwhelming evidence of efficacy with respect to the primary endpoint. The results of JUPITER have been previously published [Ridker et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2008].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe current analysis was based on the subgroup of 5695 subjects who were aged \u226570 years (median 74 years; range 70 to 97) at the time of enrollment. When compared with younger patients, those who were aged \u226570 years were more frequently female (51% vs 32%), less often obese (body mass index \u226530 kg\/m\u003Csup\u003E2\u003C\/sup\u003E, 32% vs 40%), less frequently current smokers (8% vs 19%), and more frequently had a Framingham risk score \u0026gt;10 (69% vs 41%). Overall, the relative treatment effects of rosuvastatin in individuals \u226570 years were comparable with those seen in the younger patient group. There was no difference between the age groups in the achieved lipid or hsCRP levels (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E). There was a significant 39% risk reduction in the primary composite endpoint of CV death, MI, stroke, unstable angina, or revascularization) (HR, 0.61; 95% CI, 0.46 to 0.82; p\u0026lt;0.001) in older patients who were randomized to rosuvastatin compared with those on placebo. Significant reductions were also seen for MI (HR, 0.55; 95% CI, 0.31 to 1.0; p=0.046), stroke (HR, 0.55; 95% CI, 0.33 to 0.93; p=0.023), and the incidence of revascularization or unstable angina (HR, 0.51; 95% CI, 0.33 to 0.80; p=0.003). The older subgroup was at higher risk for the primary endpoint (incidence rate 1.99\/100 person-years vs 1.06\/100 person-years in younger group) and showed a greater rate of difference on therapy compared with placebo (0.77\/100 person-years vs 0.52\/100 person-years in the younger group), with an estimated number needed to treat (NNT) for 5 years of 19 versus 29 for subjects aged \u0026lt;70 years to prevent 1 primary endpoint event.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/11366\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/11366\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11366\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EAchieved Lipid and hsCRP levels by Age.\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EThe overall risk of serious adverse events was similar for the older subgroup (HR, 1.05; 95% CI, 0.93 to 1.17; p=0.44), with the exception of incident diabetes, for which the risk that was associated with treatment was significant in younger subjects (HR, 1.26; 95% CI, 1.02 to 1.56; p=0.03) but not in the older subgroup (HR, 1.25; 95 % CI, 0.90 to 1.74; p=0.18).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EOverall, these results provide reassuring data regarding the efficacy and safety of statin therapy in elderly patients. The trial discussant, Professor Philippe Gabriel Steg, MD, INSERM U-698, Paris, France, said that the trial provides \u201csolid evidence that the benefit seen from rosuvastatin in the overall trial is seen in the elderly subgroup, including a reduction in stroke.\u201d Prof. Steg did offer caution that these findings \u201cpertain to a special population: high-risk CV patients with low LDL and elevated hsCRP\u201d and asked whether the results could be extended to patients without elevated hsCRP and to very elderly patients.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2009 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/9\/4\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmj61\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzmj61\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}