PT  - JOURNAL ARTICLE
AU  - Vinall, Phil
ED  - Dichgans, Martin
TI  - Donepezil in Subcortical Vascular Cognitive Impairment: A Randomized Double-Blind Trial in CADASIL
DP  - 2008 May 01
TA  - MD Conference Express
PG  - 14--15
VI  - 8
IP  - 1
4099  - http://mdc.sagepub.com/content/8/1/14.short
4100  - http://mdc.sagepub.com/content/8/1/14.full
AB  - Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an early-onset genetic form of subcortical ischemic vascular dementia that resembles sporadic small-vessel disease similar to VaD. The underlying pathology of CADASIL is progressive degeneration of the smooth muscle cells in blood vessels that can lead to deficits in executive functioning and cognitive processing speed. This article discusses data from a study evaluating the efficacy and safety of donepezil for patients with CADASIL.