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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ETwo ASTEROID and STRADIVARIUS trials explored the potential for pharmacologic therapy to slow the progression of atherosclerosis or even cause plaque regression in patients with coronary artery disease. The studies involved different classes of drugs and different imaging modalities to evaluate the change in the degree of stenosis caused by the atherosclerotic plaque.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Elipid disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecoronary artery disease clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003ETwo trials explored the potential for pharmacologic therapy to slow the progression of atherosclerosis or even cause plaque regression in patients with coronary artery disease (CAD). The studies involved different classes of drugs and different imaging modalities to evaluate the change in the degree of stenosis caused by the atherosclerotic plaque.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EIn the ASTEROID trial, 507 patients with angiographic evidence of CAD were treated with rosuvastatin 40 mg\/day for 24 months in an uncontrolled observational study. The initial results, first presented in 2006, demonstrated that the drug reduced plaque volume, as measured by intravascular ultrasound (IVUS), in arteries with less than 50% stenosis. Rosuvastatin 40 mg was well tolerated, with low rates of elevated ALT (1.8%) and CK (1.2%) observed, and only 12% of patients discontinuing due to adverse events. The current analysis was performed to evaluate changes in vascular lumen by quantitative coronary angiography (QCA) in arteries with more than 25% stenosis.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EChristie Ballantyne, MD, Baylor College of Medicine, Houston, TX, reported that the coronary angiograms of 292 patients were evaluated at baseline and at 24 months. QCA showed that treatment with rosuvastatin led to an increase in the mean minimal lumen diameter from 1.65 \u00b1 0.36 mm to 1.68 \u00b1 0.38 mm (p\u0026lt;0.001) and a decrease in the mean percentage diameter stenosis from 37.3 \u00b1 8.4% to 36.0\u00b1 10.1% (p\u0026lt;0.001).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EIn STRADIVARIUS, 839 abdominally obese patients with CAD were randomly assigned to treatment with either rimonabant 20 mg daily (422 patients) or placebo (417 patients). Rimonabant, a cannabanoid type 1 (CB1) receptor inhibitor, is an experimental agent that is not yet approved in the United States but is available in some European countries. The percent atheroma volume (PAV) and normalized total atheroma volume (TAV) on IVUS were determined in all patients at the beginning of the study and again at 18 months in the 676 patients who completed the trial, regardless of whether they were still taking the study drug.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003ESteven E. Nissen, MD, Cleveland Clinic, Cleveland, OH, reported that rimonabant (compared with placebo) failed to reduce the primary endpoint of PAV (+0.25% change from baseline with rimonabant vs +0.51% with placebo; p=0.22; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). However, there was a significant difference between the two groups with respect to the secondary endpoint of change in TAV from baseline (\u22122.2 mm\u003Csup\u003E3\u003C\/sup\u003E rimonabant vs +0.88 mm\u003Csup\u003E3\u003C\/sup\u003E placebo; p=0.03).\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/2\/16\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Primary and Secondary IVUS Endpoints.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-5256573\u0022 data-figure-caption=\u0022Primary and Secondary IVUS Endpoints.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/2\/16\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/2\/16\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/2\/16\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11075\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EPrimary and Secondary IVUS Endpoints.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EOf concern in the study was the higher frequency of psychiatric adverse events in the rimonabant arm (43.4% vs 28.4%; p\u0026lt;0.001). This difference was primarily driven by significant increases in anxiety (18.0% vs 11.8%; p=0.01) and depression (16.8% vs 11.3%; p=0.02). Dr. Nissen pointed out that approximately one-quarter of the patients in the study had a history of psychiatric disease at the start of the trial. The risk of psychiatric adverse events was a factor in the unanimous recommendation against approval of the drug by a U.S. Food and Drug Administration advisory panel in 2007.\u003C\/p\u003E\n         \u003Cp id=\u0022p-9\u0022\u003EThe lipid-lowering benefits of both rosuvastatin and rimonabant were confirmed by these two studies. Rosuvastatin reduced low-density lipoprotein (LDL) levels by more than 50% and increased high-density lipoprotein (HDL) levels by 14%, while rimonabant increased HDL by 22% and reduced triglyceride levels by 21%. Dr. Ballantyne noted that it may be necessary to reduce LDL by \u0026gt;50% or set a target LDL near 60 mg\/dL to induce plaque regression in coronary atherosclerosis.\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EThe results of the QCA analysis from the ASTEROID trial were published online (\u003Cem\u003ECirculation\u003C\/em\u003E 2008), and the primary results of STRADIVARIUS were published in \u003Cem\u003EJAMA\u003C\/em\u003E 2008;299:1547\u20131560.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/2\/16.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmge1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmge1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}