RT Journal Article SR Electronic A1 Jacobson, Anne T1 Data Suggest Approach to Hypertension Management Should Change JF MD Conference Express YR 2008 FD SAGE Publications VO 8 IS 2 SP 13 OP 13 DO 10.1177/155989770800800210 UL http://mdc.sagepub.com/content/8/2/13.abstract AB New data challenge the current guidelines for management of hypertension, which recommend initiating treatment with a diuretic and suggest monotherapy as the starting point of treatment. The ACCOMPLISH trial showed that a single-pill combination of an angiotensin-converting enzyme inhibitor and a calcium channel blocker led to excellent blood pressure control and significantly reduced the risk of cardiovascular events in high-risk patients.