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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n\u003Cp id=\u0022p-1\u0022\u003EThe results of the National Surgical Adjuvant Breast and Bowel Project (NSABP) C-07 trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00004931\u0026amp;atom=%2Fspmdc%2F8%2F4%2F6.atom\u0022\u003ENCT00004931\u003C\/a\u003E] demonstrated that oxaliplatin prolongs both progression-free and overall survival for patients with stage II or stage III colorectal cancer. The trial was designed to evaluate the efficacy of oxaliplatin when it was added to bolus 5-FU\/leucovorin as adjuvant treatment.\u003C\/p\u003E\n\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe results of the National Surgical Adjuvant Breast and Bowel Project (NSABP) C-07 trial (\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00004931\u0026amp;atom=%2Fspmdc%2F8%2F4%2F6.atom\u0022\u003ENCT00004931\u003C\/a\u003E) demonstrated that oxaliplatin prolongs both progression-free and overall survival (OS) for patients with stage II or stage III colorectal cancer. The trial was designed to evaluate the efficacy of oxaliplatin when it was added to bolus 5-FU\/leucovorin as adjuvant treatment.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ENorman Wolmark, MD, Chairman of the NSABP, Pittsburgh, PA, who reported the findings, noted that the study protocol called for formal analysis of OS data 5 years after the last patient was entered (November 2002). The number of deaths that actually occurred (560) was lower than the expected number (700), which reduced the protocol-specified power to detect a 0.214 reduction in the annual death rate.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EDr. Wolmark reported that oxaliplatin was associated with a trend toward better OS at both 5 years and 6 years, a difference of borderline significance (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1A\u003C\/a\u003E). In addition, the updated results on disease-free survival (DFS) showed that the effect of oxaliplatin was durable. At a mean follow-up of 67 months, there was a 19% reduction in the risk of disease progression (\u003Ca id=\u0022xref-fig-1-2\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1B\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/4\/6\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022The Combination of Oxaliplatin Plus Bolus 5-FU\/Leucovorin (FLOX) Led to Better OS (1A) and DFS (1B) Than 5-FU\/Leucovorin Alone (FULV).\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1852312821\u0022 data-figure-caption=\u0022The Combination of Oxaliplatin Plus Bolus 5-FU\/Leucovorin (FLOX) Led to Better OS (1A) and DFS (1B) Than 5-FU\/Leucovorin Alone (FULV).\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1A and 1B.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/4\/6\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/4\/6\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1A and 1B.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/8\/4\/6\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/10958\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1A and 1B.\u003C\/span\u003E \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EThe Combination of Oxaliplatin Plus Bolus 5-FU\/Leucovorin (FLOX) Led to Better OS (1A) and DFS (1B) Than 5-FU\/Leucovorin Alone (FULV).\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-6\u0022\u003EDr. Wolmark noted that the findings confirm the results of the Multicenter International Study of Oxaliplatin\/Fluorouracil\/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) trial, in which infusional combination fluorouracil and leucovorin was evaluated with and without oxaliplatin (Andre et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2004). The 5-year survival for the oxaliplatin-containing regimen in the MOSAIC trial was 81.3%, which represented an absolute difference of 2.2% (compared with 80.3% and 2.0%, respectively, in the C-07 trial). The hazard ratio for this difference was 0.85 in both studies. \u201cThe findings indicate that the benefit of oxaliplatin in terms of both overall and disease-free survival is independent of the schedule of administration [of 5-FU],\u201d said Dr. Wolmark.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EIn discussing the appropriate length of follow-up for colorectal cancer trials, Dr. Wolmark pointed out that the median survival after recurrence in NSABP trials has improved significantly over time. For example, the median survival after the C-04 trial (which began enrolling patients in 1989) was 12.7 months, compared with 19.6 months for the C-07 trial, which began enrolling patients in 2000 (p\u0026lt;0.0001). This finding, along with the significant increase in the absolute advantage of oxaliplatin in the C-07 trial, indicates that future trials of adjuvant therapy should utilize longer follow-up (beyond five years) in order to reliably detect differences in OS, he said.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/4\/6.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmfbq\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmfbq\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}