<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vinall, Maria</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Jones, Graeme</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">The AMBITION Study</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">14-15</style></pages><abstract><style  face="normal" font="default" size="100%">Although studies have shown current anti-TNF treatments to be superior to short-term methotrexate (ie, before 24 weeks), none has shown superiority at Week 24. The AMBITION study [NCT00109408] showed that after 24 weeks, tocilizumab (an anti-IL-6 receptor antibody that inhibits IL-6 signaling) monotherapy was clinically superior to methotrexate (MTX) monotherapy in patients with rheumatoid arthritis who have not failed previous MTX or biologic treatment.</style></abstract><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">8</style></volume></record></records></xml>