PT  - JOURNAL ARTICLE
AU  - Vinall, Maria
ED  - Eastell, Richard
TI  - Effect of Previous Bisphosphonate Use on Response to Zoledronic Acid
DP  - 2008 Sep 01
TA  - MD Conference Express
PG  - 14--14
VI  - 8
IP  - 5
4099  - http://mdc.sagepub.com/content/8/5/14.1.short
4100  - http://mdc.sagepub.com/content/8/5/14.1.full
AB  - The HORIZON Pivotal Fracture Trial [NCT00049829] showed that once-yearly zoledronic acid significantly reduces the risk of vertebral, hip, and other fractures [Black D et al. N Engl J Med 2007]. This article discusses the results of a planned subanalysis from HORIZON that evaluated the effect of prior bisphosphonate use on the primary endpoints of new vertebral fracture (in patients who were not taking concomitant osteoporosis medications) and non-vertebral fractures (in all patients).