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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe HORIZON Pivotal Fracture Trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00049829\u0026amp;atom=%2Fspmdc%2F8%2F5%2F14.1.atom\u0022\u003ENCT00049829\u003C\/a\u003E] showed that once-yearly zoledronic acid significantly reduces the risk of vertebral, hip, and other fractures [Black D et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2007]. This article discusses the results of a planned subanalysis from HORIZON that evaluated the effect of prior bisphosphonate use on the primary endpoints of new vertebral fracture (in patients who were not taking concomitant osteoporosis medications) and non-vertebral fractures (in all patients).\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Emetabolic bone disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Emetabolic bone disease clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EThe HORIZON Pivotal Fracture Trial (\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00049829\u0026amp;atom=%2Fspmdc%2F8%2F5%2F14.1.atom\u0022\u003ENCT00049829\u003C\/a\u003E) was a 3-year, double-blind, randomized, placebo-controlled trial in which patients received a 15-minute infusion of zoledronic acid 5 mg (n=3889) or placebo (n=3876) at baseline and at 12 and 24 months. Results, previously reported by Black and colleagues, showed that once-yearly zoledronic acid significantly reduces the risk of vertebral, hip, and other fractures [Black D et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2007].\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003ERichard Eastell, MD, PhD, University of Sheffield, Sheffield, UK, presented the results of a planned subanalysis from HORIZON that evaluated the effect of prior bisphosphonate use on the primary endpoints of new vertebral fracture (in patients who were not taking concomitant osteoporosis medications) and non-vertebral fractures (in all patients). Markers of bone turnover were also evaluated.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EBisphosphonates had been used by 565 patients (14.5%) in the zoledronic acid group and 557 patients (14.4%) in the placebo group. The duration of the washout period was dependent on previous use (eg, 2 years if previous use was\u226548 weeks).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EOver 3 years, the incidence of vertebral fracture was significantly (p\u0026lt;0.0001) lower in the zoledronic acid group versus the placebo group regardless of prior bisphosphonate.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003ESignificant (p\u0026lt;0.001) reductions in the incidence of non-vertebral fractures also were seen in bisphosphonate-na\u00efve patients who were treated with zoledronic acid (n=237, 7.60%) versus placebo (n=337, 10.88%), but not in patients who previously had used bisphosphonates (n=54, 10.11% vs n=50, 9.80%).\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EOver 3 years, changes in markers of bone turnover were similar between the bisphosphonate use groups. Reductions from baseline at Month 36 in serum levels of c-telopeptides, bone alkaline phosphatase, and N-terminal propeptide of type I collagen with zoledronic acid relative to placebo were 53.8%, 30.0%, and 48.4%, respectively, in the bisphosphonate-naive group, and 49.3%, 16.1%, and 50.1%, respectively, in the previous bisphosphonate use group.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThe benefits of once-yearly zoledronic acid that were observed during a 3-year period were robust on vertebral fractures, bone turnover markers, and bone mineral density, regardless of whether patients had previously received bisphosphonate treatment. Zoledronic acid had a favorable safety profile and generally was well tolerated.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/5\/14.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmemp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}