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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ESystemic onset JIA (SoJIA) is unique in terms of its clinical manifestations, prognosis, and response to therapy. This article presents results of a multicenter randomized double-blind trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00339157\u0026amp;atom=%2Fspmdc%2F8%2F5%2F12.atom\u0022\u003ENCT00339157\u003C\/a\u003E] conducted in patients with SoJIA where the objectives were to investigate immunological mechanisms underlying the disease and assess the effect of anakinra at a transcriptional level using patient blood transcriptional profiles.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Erheumatological autoimmune disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Earthritis clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003ESystemic onset JIA (SoJIA) is unique in terms of its clinical manifestations, prognosis, and response to therapy. Previous studies have shown the importance of IL-1b in the pathogenesis of SoJIA [Pascual V et al. \u003Cem\u003EJ Exp Med\u003C\/em\u003E 2005] and the beneficial effects of anti-IL1 in controlling the clinical manifestations of the disease [Allantaz F. \u003Cem\u003EJ Exp Med\u003C\/em\u003E 2007; Verbsky JW and White AJ. \u003Cem\u003EJ Rheumatol\u003C\/em\u003E 2004].\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EFlorence Allantaz, PhD, Baylor Institute for Immunology Research, Dallas, TX, presented the results of a multicenter randomized double-blind trial (\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00339157\u0026amp;atom=%2Fspmdc%2F8%2F5%2F12.atom\u0022\u003ENCT00339157\u003C\/a\u003E) conducted in patients with SoJIA (n=24). The objectives of the study were to investigate immunological mechanisms underlying the disease and assess the effect of anakinra at a transcriptional level using patient blood transcriptional profiles. During the double-blind phase of the study (Month 1) patients received either anakinra (2 mg\/kg\/day; maximum 100 mg) or placebo; patients received anakinra for the remaining 5 months.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EBlood samples were collected at enrollment and at Months 1 and 6. Whole blood RNA was hybridized to Illumina Human 6-v2 chips. A module-based data mining strategy, which focused the analysis of microarray data on stable sets of transcripts selected on the basis of their clustering pattern across diseases, was used.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EAt Day 1, modular analysis showed significantly increased expression of genes related to cells of the myeloid lineage (ie, monocytes and neutrophils, inflammation, red blood cells, and coagulation-related genes), reflecting a strong activation of the innate immune response. Dr. Allantaz and colleagues also observed a consistent down-regulation of genes regulating adaptive immunity, including genes associated with B cell, T cell and cytotoxic cell function of genes involved in immunosuppression were also downregulated. After 6 months of treatment with anakinra, the dysregulation of those modules rapidly disappeared in 13\/19 patients, indicating that anakinra is an effective treatment for SoJIA.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EThis analysis also showed that IFN-regulated genes were induced with anakinra treatment. One month of treatment was sufficient to induce significant changes in modular expression and allow the investigators to distinguish patients treated with anakinra from patients treated with placebo. Modular analyses at Months 1 and 6 also showed clear differences between responders and nonresponders.\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EDr. Allantaz stated, \u201cUsing a modular based approach we were able to identify a set of gene pathways dysregulated in SoJIA whose expression dramatically changed upon anakinra treatment in a group of patients.\u201d\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThe safety and efficacy results of this trial were also presented during the EULAR 2008 Annual Meeting [Abstract OP-0061] and have recently been published [Quartier P et al. \u003Cem\u003EAnn Rheum Dis\u003C\/em\u003E 2008;67(Suppl II):68].\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/5\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmeg1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}