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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EIn a study that had a 5-year follow-up, hippocampal volume (HV) was shown to be correlated with elevated risk in a cohort of elderly patients with mild cognitive impairment. Individuals who developed dementia had a smaller HV at baseline.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Edementias\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecognitive disorders clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EIn a study that had a 5-year follow-up, hippocampal volume (HV) was shown to be correlated with elevated risk in a cohort of elderly patients with mild cognitive impairment. Individuals who developed dementia had a smaller HV at baseline.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPatients with minimal cognitive impairment (MCI) as identified by the Clinical Dementia Rating scale (CDR) are known to have a conversion rate to dementia of 20%. The CDR Sum of Boxes score (CDR-SB; range 0\u201318) enables a quantitative evaluation of that impairment. To evaluate HV as a predictor of conversion, this study assessed 28 elderly patients who had a range of impairment at baseline. Impairment was gauged with the instruments of CDR-SB, MMSE (mini mental state examination), and ADAS-cog (Alzheimer assessment scale). Based on these outcomes, patients were stratified as follows:\u003C\/p\u003E\n         \u003Cul class=\u0022list-unord \u0022 id=\u0022list-1\u0022\u003E\u003Cli id=\u0022list-item-1\u0022\u003E\n               \u003Cp id=\u0022p-4\u0022\u003ECDR=0 (thus CDR-SB=0) = low risk\u003C\/p\u003E\n            \u003C\/li\u003E\u003Cli id=\u0022list-item-2\u0022\u003E\n               \u003Cp id=\u0022p-5\u0022\u003ECDR=0.5 and CDR-SB=0.5, 1, or 1.5 = medium risk\u003C\/p\u003E\n            \u003C\/li\u003E\u003Cli id=\u0022list-item-3\u0022\u003E\n               \u003Cp id=\u0022p-6\u0022\u003ECDR=0.5 and CDR-SB=2, 2.5, or 3 = high risk\u003C\/p\u003E\n            \u003C\/li\u003E\u003C\/ul\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EHippocampal volume was determined with a brain MRI within a maximum 4-month period after the initial neuropsychological evaluation. Scans were performed with a GE 1.5 Telsa scanner; imaging data were analyzed with Brains 2 software.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EResults showed that HV was significantly smaller in high-risk individuals (0.21\u00b10.014) as compared with individuals who were considered to be at low risk (0.28\u00b10.033) or medium risk (0.26\u00b10.037; p\u0026lt;0.001 for both). Those who went on to develop dementia two years before the final neuropsychological assessment had a smaller mean HV at baseline than those who did not (p=0.02); however, after receiver operating characteristic analysis was performed, no discrete HV value emerged as being useful to discriminate between the two groups. The HV correlated negatively with CDR-SB but did not correlate with age or years of education. The finding that individuals who developed dementia had smaller HV at baseline supports the theory that HV may be an important predictor of conversion.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2008 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/8\/3\/16.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmdxq\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}