RT Journal Article
SR Electronic
A1 Canavan, Neil
T1 ER Stress Induces Beta-Cell Apoptosis
JF MD Conference Express
YR 2008
FD SAGE Publications
VO 8
IS 7
SP 29
OP 30
DO 10.1177/155989770800800714
UL http://mdc.sagepub.com/content/8/7/29.abstract
AB A growing consensus links the loss of beta-cell mass with the development of type 2 diabetes mellitus. This article demonstrates that endoplasmic reticulum stress, induced by high levels of saturated free fatty acids, triggers a response that leads to eventual beta-cell apoptosis. This observation suggests one or more new targets for the therapeutic maintenance of beta-cell populations.