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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n\u003Cp id=\u0022p-1\u0022\u003ESuccinobucol (AGI-1067) is a novel compound believed to reduce inflammation in blood vessel walls. This article gives an overview of the findings from the Phase 3 randomized, double-blind Aggressive Reduction of Inflammation Stops Events [ARISE] study.\u003C\/p\u003E\n\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ESuccinobucol (AGI-1067) is a novel compound believed to reduce inflammation in blood vessel walls. Jean-Claude Tardif, MD, of the Montreal Heart Institute gave an overview of the findings from the Phase 3 randomized, double-blind Aggressive Reduction of Inflammation Stops Events (ARISE) study. This study, conducted at 261 sites in the United States, Canada, South Africa, and the United Kingdom, compared succinobucol to placebo in 6,144 patients with acute coronary syndrome (ACS). Eligible patients had been hospitalized 14 to 365 days prior to study entry with an acute myocardial infarction (MI) or unstable angina. The primary endpoint of the study was a composite of cardiovascular (CV) death, resuscitated cardiac arrest, MI, stroke, unstable angina, or coronary revascularization.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThere were no significant differences between the succinobucol 300 mg\/day group (n=3,078) and the placebo group (n=3,066) in terms of baseline demographic variables. The study failed to meet its primary endpoint and the survival curves of the two treatment groups were virtually identical.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003E\u201cThe two Kaplan-Meier curves are almost super-imposed and in fact there was an almost identical number of primary events in both study groups. Basically the primary endpoint could not be more neutral than this,\u201d commented Dr. Tardif. Heart failure hospitalizations were higher in the succinobucol group. Succinobucol also caused a significant rise in low density lipoprotein-cholesterol (LDL-C; p\u0026lt;0.0001) and a significant decrease in high density lipoprotein-cholesterol (HDL-C; p\u0026lt;0.0001).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EIn a secondary measure of combined athero-thrombotic endpoints including CV death, cardiac arrest, MI, and stroke, a significant decrease was observed with succinobucol therapy (hazard ratio=0.81; 95% CI, 0.68 to 0.98; p=0.028). Other secondary analyses indicated that the time to new onset of diabetes was significantly reduced in the succinobucol arm, a finding that was further supported by improvement in glycated hemoglobin A1c and glucose (all p\u0026lt;0.001 vs placebo).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ESerious adverse event rates were similar between the two groups. The most common adverse event associated with succinobucol was diarrhea (23% vs 8% for placebo). Although the study did not meet its primary endpoint, the investigators remain optimistic about the future of the drug.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2007 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/7\/1\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmbe2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}