PT  - JOURNAL ARTICLE
AU  - Vinall, Phil
ED  - Källberg, Henrik
TI  - Alcohol Consumption is Associated with Decreased Risks for Developing Rheumatoid Arthritis: Results from the Swedish EIRA Study
DP  - 2007 Sep 01
TA  - MD Conference Express
PG  - 13--14
VI  - 7
IP  - 4
4099  - http://mdc.sagepub.com/content/7/4/13.short
4100  - http://mdc.sagepub.com/content/7/4/13.full
AB  - In a recent study in mice [Jonsson IM et al. Proc Natl Acad Sci 2007], alcohol consumption prevented development of destructive arthritis. This anti-inflammatory and anti-destructive property of alcohol was mediated by down-regulation of leukocyte migration and upregulation of testosterone secretion, with the latter leading to decreased NF-kappaB activation. This article discusses the Epidemiological Investigation of Rheumatoid Arthritis [EIRA] study is a population based case-control study of incident cases of RA among 1,419 subjects aged 18–70 years in a defined area of Sweden.