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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EVertebral fractures in postmenopausal women (\u0026lt;65 years of age) with osteoporosis can lead to acute and chronic back pain, loss of weight, reduced pulmonary function, back related disability, depression, and a sustained decrease in quality of life. Early fractures occurring within the first 10 years after menopause are especially troublesome since they are a major risk factor for further additional fractures.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EVertebral fractures in postmenopausal women (\u0026lt;65 years of age) with osteoporosis can lead to acute and chronic back pain, loss of weight, reduced pulmonary function, back related disability, depression, and a sustained decrease in quality of life. Early fractures occurring within the first 10 years after menopause are especially troublesome since they are a major risk factor for further additional fractures.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EStrontium ranelate is an anti-osteoporotic treatment with a unique mode of action which reduces bone resorption while promoting continued bone formation [Marie PJ et al. \u003Cem\u003ECalcif Tissue Int\u003C\/em\u003E 2001]. It has been shown to be effective in reducing the risk of vertebral fractures in two phase 3 studies. In the Spinal Osteoporosis Therapeutic Intervention (SPOTI) study of 1,649 postmenopausal women (mean age 69.4\u00b17.2) with osteoporosis, strontium ranelate 2g\/day produced a risk reduction for vertebral fracture of 49% in the first year and 41% over 3 years [Meunier PJ et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2004]. The Treatment of Peripheral Osteoporosis (TROPOS) study was designed to examine the effect of strontium ranelate on non-vertebral fractures in postmenopausal women with osteoporosis (mean age 76.7\u00b18). Three thousand six hundred and forty (3,640) of the 5,091 patients had spine X-rays, which showed a risk reduction of 45% at 1 year and 39% over 3 years [Reginster JY et al. \u003Cem\u003EJ Clin Endocrinol Metab\u003C\/em\u003E 2005].\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe objective of this study, presented at EULAR by Prof. Roux, Ren\u00e9 Descartes University, Paris, was to assess the efficacy of strontium ranelate in the reduction of vertebral fracture risk in women between the ages of 50 and 65 using data from the SPOTI study.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EWomen in this database (168 treated with strontium ranelate; 185 in the placebo group) had a mean age of 60.0\u00b13.5 years, lumbar bone mineral density (BMD) T-score of \u22123.6\u00b11.1, and a femoral neck BMD T-score of \u22122.5\u00b10.8; 80.5% of the patients had a prevalent vertebral fracture and 23.0% had a prevalent non-vertebral fracture.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003ETreatment with strontium ranelate, reduced the relative risk of vertebral fractures by 47% over 3 years, and by 40% over 4 years (p=0.006). The incidence of vertebral fractures over 3 years was 16.9% in the strontium ranelate treated group vs 29.6% in the placebo treated group (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E).\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/7\/4\/12.2\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Reduction of Vertebral Fracture Risk in Younger Patients.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-252372289\u0022 data-figure-caption=\u0022Reduction of Vertebral Fracture Risk in Younger Patients.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1:\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/7\/4\/12.2\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/7\/4\/12.2\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1:\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/7\/4\/12.2\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11153\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1:\u003C\/span\u003E \n               \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EReduction of Vertebral Fracture Risk in Younger Patients.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThe reduction in the risk of vertebral fracture was paralleled by a significant increase (14.6%; p\u0026lt;0.001) in the relative change from baseline of lumbar BMD after 3 years, and by 7.5% in the relative change from baseline of femoral neck BMD vs placebo. Nausea, diarrhea, headache, and dermatitis were the most reported adverse events, none of which were significantly different from placebo.\u003C\/p\u003E\n         \u003Cp id=\u0022p-9\u0022\u003EStrontium ranelate significantly reduces vertebral fractures in postmenopausal women \u0026lt;65 years of age with severe osteoporosis.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2007 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/7\/4\/12.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzm9b1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm9b1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}