PT - JOURNAL ARTICLE AU - Helwick, Caroline ED - Freeman, Roy TI - Diabetic Peripheral Neuropathy: More Effective Treatments Needed DP - 2007 Dec 01 TA - MD Conference Express PG - 26--27 VI - 7 IP - 6 4099 - http://mdc.sagepub.com/content/7/6/26.short 4100 - http://mdc.sagepub.com/content/7/6/26.full AB - In a pooled analysis of 1,510 patients enrolled in seven randomized controlled trials, pregabalin (150–600 mg/day) provided significant improvements in pain, sleep interference due to pain, and global health. Improvements in pain were dose-related; a clinically meaningful (=30%) improvement in pain was noted by 43%–62%, though 37% of placebo patients also reported this level of improvement.