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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ESeveral large studies have shown that in diabetic patients, HbA1C is a strong predictor of cardiovascular disease, while in non-diabetics, this association is less clear. This article discusses results of the first study to examine the association of HbA1C with non-fatal cardiovascular disease in non-diabetics.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Ehyperglycemia\/hypoglycemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ediabetes \u0026amp; endocrinology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003ESeveral large studies have shown that in diabetic patients, HbA1c is a strong predictor of cardiovascular disease, while in non-diabetics, this association is less clear. Results of the first study to examine the association of HbA1c with non-fatal cardiovascular disease in non-diabetics were reported by Esther van\u0027t Riet, VU University Medical Center, Amsterdam, the Netherlands. The results showed that, even in non-diabetics, HbA1c elevation significantly increases the risk for non-fatal cardiovascular events.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EThe Hoorn Study is a population based cohort study of a general population in the Netherlands. The current analysis of cardiovascular events was based on data from 1,674 non-diabetic subjects from the Hoorn Study for whom data on Hb1Ac level, glucose level, and morbidity were available. Over the course of approximately 10 years, 385 non-fatal and 113 fatal cardiovascular events had occurred.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EEsther van\u0027t Riet reported that whether adjusting only for age and gender or for age and gender plus other traditional cardiovascular risk factors (eg, hypertension, smoking, LDL-cholesterol, triglycerides, and waist-to-hip ratio), subjects with HbA1c \u0026gt;5.6% had a significantly increased risk of a non-fatal cardiovascular event (p\u0026lt;0.05).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EThis association with fatal cardiovascular events was significant in the model that included only age and gender, but not when adjusted for the other traditional cardiovascular risk factors.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003E\u201cThe clinical meaning of this is that, even in subjects without diabetes, it is very important to maintain optimal glycemic control,\u201d she said. She added, however, that control of blood pressure and cholesterol are still more important than addressing HbA1c.\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EThe study also examined the relationship between fasting plasma glucose and 2-hour-plasma glucose, finding no significant associations with cardiovascular disease, after correction for age, gender and other cardiovascular risk factors. Miss. van\u0027t Riet speculated that the reason there was no association with 2-hour-plasma glucose (a relationship that has been reported in prior epidemiological studies) was that diabetic patients were excluded in the current analysis, whereas they were included in the previous studies. In addition, previous research not always adjusted for traditional cardiovascular disease risk factors.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2007 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/7\/6\/10.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm7x2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}