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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EAlthough oral MTX for the treatment of RA has been shown to be effective, adverse events may lead to discontinuation of treatment. This study reports the 24-week comparison of the safety and efficacy of subcutaneous (sc) vs orally administered MTX in patients with active RA.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Erheumatoid arthritis clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EAlthough oral MTX for the treatment of RA has been shown to be effective, adverse events may lead to discontinuation of treatment. This study reports the 24-week comparison of the safety and efficacy of subcutaneous (sc) vs orally administered MTX in patients with active RA. Patients with insufficient oral responses were switched to sc application or dose augmentation after 4 months.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPatients were randomly assigned to 15 mg oral MTX (two 7.5 mg tablets + a dummy pre-filled syringe) or sc MTX (15 mg via a pre filled syringe at 10mg\/ml + dummy tablets) given weekly until week 24. At week 16 ACR20 nonresponders were switched from oral MTX to 15 mg sc and from 15 mg MTX sc to 20 mg sc for the remaining 8 weeks in a blinded fashion, respectively. The primary outcome parameters were the ACR20 after 24 weeks. Secondary outcome parameters were ACR50\/70\/90 and DAS28\/EULAR response criteria after 24 weeks, and time to onset of ACR20.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EOnly 15% of the patients were classified as ACR20 nonresponders at week 16 and switched medication. After 24 weeks the sc route of MTX application yielded a significantly higher efficacy in various relevant parameters including improvement in ACR20\/50\/70 response rates and EULAR response rates compared to the oral administration. Remission (defined as DAS28 \u0026lt;2.6) was achieved by 34% of the sc MTX patients compared with 24% of the oral MTX treated patients (p\u0026lt;0.05).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EIn this first of kind study, the authors concluded that MTX given sc is significantly more effective than the oral form.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/3\/16.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm5dd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}