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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EPsoriatic arthritis (PsA) is a chronic inflammatory arthropathy condition characterized by an association of arthritis and psoriasis that can lead to progressive joint damage, disability, and reduced life expectancy [\u003Cem\u003ERheumatol\u003C\/em\u003E 2003;42:1460\u20148]. Using data from the 54 week IMPACT 2 trial data, this article assesses the effect of IFX 5mg\/kg compared with a placebo on structural damage in 200 PsA patients.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Erheumatology clinical trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Earthritis\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EPsoriatic arthritis (PsA) is a chronic inflammatory arthropathy condition characterized by an association of arthritis and psoriasis that can lead to progressive joint damage, disability, and reduced life expectancy (\u003Cem\u003ERheumatol\u003C\/em\u003E 2003;42:1460\u20138). A substantial proportion of patients have persistent inflammation. The extent of radiographic progression in patients with established PsA is comparable with that of RA patients when matched for age, sex, and disease duration (\u003Cem\u003ERheumatol\u003C\/em\u003E 2001;28:1041\u20134).\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EHistorically, the decision to use a particular treatment modality for PsA has been mainly derived from the extrapolation of data from patients with RA. Results from the recent Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT), indicated that therapy with infliximab (IFX) 5 mg\/kg significantly improved the signs and symptoms of arthritis, as well as reduced skin psoriasis, in patients with active PsA resistant to prior DMARD therapy (\u003Cem\u003EArthritis Rheum\u003C\/em\u003E 2005;52:1227\u201336).\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EUsing data from the 54 week IMPACT 2 trial data, the authors assessed the effect of IFX 5mg\/kg compared with a placebo on structural damage in 200 PsA patients. Radiographic data was obtained from hand and feet measurements at weeks 0, 24, and 54. Erosions and joint space narrowing were evaluated by the van der Heijde-Sharp method modified for PsA.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003ERadiographic data indicated that IFX was an effective inhibitor of radiographically documented progression of joint structural damage. At week 24, IFX-treated patients had significantly less radiographic damage than placebo patients (mean change in total van der Heijde-Sharp score = \u22120.70 \u00b1 2.53 vs 0.82 \u00b1 2.62, p\u0026lt;0.001). Twelve placebo-treated patients vs 3 patients in the IFX group had changes in the total van der Heijde-Sharp scores exceeding the the smallest detectable change at week 24 (p = 0.017). In patients continued on IFX through week 46, mean change was \u22120.94 vs 0.53 in patients who crossed over from placebo to IFX (p=0.001). These results indicate that IFX provides effective inhibition of radiographic progression in PsA patients as early as 24 weeks and continues to provide protection after 1 year of treatment.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/3\/15.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm5dd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}