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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe Myoblast Autologous Grafting in Ischemic Cardiomyopathy [MAGIC] Trial examined the safety and efficacy of autologous skeletal myoblast cell therapy for improving local or global cardiac contractility in patients with ischemic heart failure. This is the first multi-center, randomized, double blind and placebo controlled trial of skeletal myoblast implantation and one that is designed with the power sufficient to determine whether autologous grafting is a viable solution for ischemic cardiomyopathy.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Ecardiology clinical trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Einterventional techniques \u0026amp; devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Einflammatory disease genomics\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EThe Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial examined the safety and efficacy of autologous skeletal myoblast cell therapy for improving local or global cardiac contractility in patients with ischemic heart failure. This is the first multicenter, randomized, double blind and placebo controlled trial of skeletal myoblast implantation and one that is designed with the power sufficient to determine whether autologous grafting is a viable solution for ischemic cardiomyopathy.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPatients were randomized to three parallel groups: 33 patients received a low dose of smooth muscle cells (SMC; 400 \u00b1 100 \u00d7 10\u003Csup\u003E6\u003C\/sup\u003E cells), 33 patients received a high dose of SMC (800 \u00b1 100 \u00d7 10\u003Csup\u003E6\u003C\/sup\u003E cells), and 34 patients received placebo consisting of suspension medium alone. All but eight patients had concomitant coronary artery bypass grafting (CABG) in non-cell transplanted segments. According to lead investigator Philippe Menasch\u00e9, MD, H\u00f4pital Bichat, Paris, it is important to note that \u201cin almost all cases, cells were placed where the heart muscle was not previously revascularized.\u201d\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe study failed to reach its primary endpoint of improving the contractility of the heart (left ventricle ejection fraction, or LVEF, as measured by echocardiography). The pre-specified secondary endpoint of decreasing left ventricular dilation, however, reached statistical significance at six months. In the placebo or low dose group there was no change, but there was a major decrease in dilation in the high dose group (p=0.006). In half of the patients, LVEF was measured by radionuclide angiography, and in this cohort of patients the increase in ejection fraction was statistically significant (3%) in the high dose group (p=0.04).\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EDue to concerns that skeletal myoblasts may be proarrythmogenic, as they fail to integrate electro-mechanically to the surrounding myocardium, defibrillators were implanted in all patients prior to hospital discharge. These devices were used to determine time to first ventricular arrhythmia, which was deemed not significantly different between the three groups at 6 months.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003E\u201cI can tell you that now half of the patients have completed one year of the study and there is still no difference in ventricular arrhythmias between the groups,\u201d commented Dr. Menasch\u00e9, when emphasizing the safety of the procedure.\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003E\u201cWhile there was absence of significant improvement of regional and or global contractility measured by echocardiography, there is possible evidence for reversal of adverse remodeling,\u201d concluded Dr. Menasch\u00e9. He also emphasized that long-term follow up results are often more important than interim results and the discovery of long-term benefit may lie ahead.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/5\/21.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm4od\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}