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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ECetuximab plus chemotherapy and radiation therapy does not improve clinical complete response rates or overall survival (OS) in patients with locally advanced esophageal cancer. This article presents data from the Paclitaxel, Cisplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Locally Advanced Esophageal Cancer trial [RTOG 0436; Ilson D et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0005)].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHead \u0026amp; Neck Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EHead \u0026amp; Neck Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ECetuximab plus chemotherapy and radiation therapy does not improve clinical complete response (cCR) rates or overall survival (OS) in patients with locally advanced esophageal cancer. David H. Ilson, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, New York, USA, presented data from the Paclitaxel, Cisplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Locally Advanced Esophageal Cancer trial [RTOG 0436; Ilson D et al. \u003Cem\u003EAnn Oncol\u003C\/em\u003E 2014 (abstr O-0005)].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ECetuximab is a monoclonal antibody that blocks the EGFR and inhibits tumor growth by preventing blood flow to the tumor. The purpose of the RTOG 0436 trial was to determine if the addition of cetuximab to paclitaxel and cisplatin plus radiation therapy would improve outcomes in patients with locally advanced esophageal cancer.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn the Phase 3 RTOG 0436 trial, 328 patients with adenocarcinoma or squamous cell carcinoma of the esophagus were randomly assigned to receive paclitaxel plus cisplatin and radiation (50.4 Gy\/1.8 Gy fractions) with or without cetuximab. Patients were eligible if their endoscopic ultrasound (EUS) stage was T1N1M0, T2 to T4 any N M0, or any T or N M1a, and patients were stratified by histology, tumor size, and the presence of celiac lymph nodes. The primary end point of the RTOG 0436 trial was OS. Baseline characteristics were similar among treatment arms, with T3\/4 disease present in 80% of patients, N1 in 66%, and celiac lymph nodes in 19%.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EDuring the median follow-up period of 15.4 months, cCR rates were similar between both treatment arms (p = .72), regardless of stratification by histology. In patients who achieved cCR, the 12- and 24-m OS rates were, respectively, 79% and 58% compared with 53% and 30% in patients with residual disease (p \u0026lt; .0001); however, there was no significant difference between treatment arms.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EDr. Ilson stated that, in his opinion, the data from the RTOG 0436 trial indicated that the addition of cetuximab to concurrent chemotherapy and radiation therapy does not improve cCR rates or prolong OS in patients with esophageal cancer, regardless of histology. Therefore, the data from this trial suggest that there is currently no evidence for the use of EGFR-targeted therapies in addition to concurrent chemotherapy and radiation therapy for the treatment of esophageal cancer.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/22\/12.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm2tp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}