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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EA new analysis from the DASISION trial showed that long-term treatment with dasatinib, compared with imatinib, in patients with treatment-na\u00efve, chronic phase myeloid leukemia improved rates of major molecular response and molecular response, but not overall survival or progression-free survival, in the patients who completed 5 years of follow-up, without new safety signals.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Elong-term treatment\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Enewly diagnosed chronic myeloid leukemia\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Emolecular response\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eoverall survival\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eprogression-free survival\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group drug\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Edasatinib\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eimatinib\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EPhase 3 Study of Dasatinib Versus Imatinib in Patients With Newly Diagnosed Chronic Phase CML\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDASISION\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENCT00481247\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EAfter 5 years of follow-up, patients with chronic-phase chronic myeloid leukemia (CML) who were treated with dasatinib experienced greater rates of major molecular response (MMR) and molecular response (MR), but similar rates of overall survival (OS) and progression-free survival (PFS) compared with patients treated with imatinib. Jorge Cortes, MD, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, presented the final 5-year data from the Phase 3 Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase CML [DASISION; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00481247\u0026amp;atom=%2Fspmdc%2F14%2F55%2F19.atom\u0022\u003ENCT00481247\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EDasatinib is a first-line treatment for patients with chronic-phase CML. In the DASISION trial, patients with chronic-phase CML who received dasatinib demonstrated higher rates of complete cytogenic response (CCyR) and a faster rate of attaining MR with an acceptable safety profile compared with patients who received imatinib [Kantarjian H et al. \u003Cem\u003EN Engl J Med.\u003C\/em\u003E 2010]. The purpose of the present analysis was to determine the long-term outcomes of patients who completed a minimum of 5 years of follow-up.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe multicenter DASISION trial randomly assigned 519 treatment-na\u00efve patients with chronic-phase CML to receive dasatinib 100 mg QD (n\u2009=\u2009259) or imatinib 400 mg QD (n\u2009=\u2009260) [Kantarjian H et al. \u003Cem\u003EN Engl J Med.\u003C\/em\u003E 2010]. The primary end point of confirmed CCyR by 12 months was reached by 77% of patients in the dasatinib arm compared with 66% of patients in the imatinib arm (\u003Cem\u003EP\u003C\/em\u003E\u2009=\u2009.007).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EBy 5 years, the MMR rates were 76% and 64% in the dasatinib and imatinib arms, respectively (\u003Cem\u003EP\u003C\/em\u003E\u2009=\u2009.0022); the difference between the 2 arms remained similar over the 5-year period. MR was achieved by 42% and 33% of patients in the dasatinib and imatinib arms, respectively (\u003Cem\u003EP\u003C\/em\u003E\u2009=\u2009.0251). However, the 5-year OS and PFS were similar among both arms, with rates of 91.5% (HR, 1.01; 95% CI, 0.58 to 1.73) and 85.5% (HR, 1.06; 95% CI, 0.68 to 1.66), respectively. A greater number of patients in the imatinib arm (7.3%) experienced transformation to accelerated or blastic phase CML compared with the dasatinib arm (4.6%).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003E\n            \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E outlines the outcomes at 5 years in relation to the MR at 3 months; patients in both treatment groups whose BCR-ABL levels were \u2264\u200910% at 3 months had better outcomes.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/11575\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/11575\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11575\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EBest 5-Year Responses by Molecular Response at 3 Months\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-10\u0022\u003EIn addition, 5-year OS, PFS, and transformation-free survival were significantly higher in patients whose BCR-ABL levels were \u2264\u200910% at 3 months in both arms of the study compared with patients whose BCR-ABL levels were \u0026gt;\u200910% (\u003Ca id=\u0022xref-table-wrap-2-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T2\u0022\u003ETable 2\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022T2\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/11578\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/11578\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11578\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 2.\u003C\/span\u003E \u003Cp id=\u0022p-11\u0022 class=\u0022first-child\u0022\u003EFive-Year Outcomes by Molecular Response at 3 Months\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-14\u0022\u003ETreatment failure occurred in 10 patients in the dasatinib arm and 14 patients in the imatinib arm, and disease progressed in 18 patients in the dasatinib arm and 23 patients in the imatinib arm. Mutations were identified in some patients whose treatment failed or disease progressed, and most of these patients discontinued the study early.\u003C\/p\u003E\u003Cp id=\u0022p-15\u0022\u003EImportant adverse events included pleural effusion, which occurred in 28% of patients who received dasatinib and only 1% of patients who received imatinib. In addition, arterial ischemic events such as myocardial infarction, angina pectoris, coronary artery disease, acute coronary syndromes, and transient ischemic attack occurred more frequently in the dasatinib arm. Other adverse events reported more frequently in the dasatinib arm included abdominal pain and headache, whereas facial edema, muscle spasms, myalgia, nausea, and vomiting occurred more frequently in the imatinib arm.\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003EIn conclusion, Dr Cortes stated that the 5-year data from the DASISION trial support the data from earlier analyses showing that dasatinib treatment resulted in higher rates of MMR and MR, faster time to MR, and less frequent transformation to accelerated or blastic CML. No new safety signals occurred. Although arterial ischemic events were more frequent with dasatinib treatment, they were uncommon.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/55\/19.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm2le\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzm2le\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}