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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EStereotactic body radiotherapy (SBRT) is a treatment option for patients with non-small cell lung cancer (NSCLC) who are not eligible for surgical intervention. The staging workup for patients with NSCLC receiving stereotactic SBRT requires an initial positron emission tomographic (PET) imaging. This article analyzes the use of invasive mediastinal staging methods compared to PET imaging alone in patients with NSCLC.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERespiratory Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERespiratory Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EInvasive mediastinal staging methods did not provide added outcome benefits over positron emission tomographic (PET) imaging alone in patients with non-small cell lung cancer (NSCLC). Roy Decker, MD, PhD, Yale University School of Medicine, New Haven, Connecticut, USA, presented data from this retrospective analysis.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EStereotactic body radiotherapy (SBRT) is a treatment option for patients with NSCLC who are not eligible for surgical intervention. The staging workup for patients with NSCLC receiving stereotactic SBRT requires an initial PET imaging. However, in some cases, nodal status is confirmed by mediastinoscopy or endobronchial ultra-sonography. The supplementary information obtained by these invasive mediastinal procedures has not been well studied in NSCLC. This study assessed whether additional staging improved outcomes in patients with NSCLC.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 286 patients with early-stage NSCLC who received either PET-only (68%) or PET-plus-invasive mediastinal staging (32%) were included in the analysis. Patients with larger tumors (\u0026gt; 3 cm), synchronous primary lesions, and central lesions were more likely to receive PET-plus-invasive mediastinal staging. Survival distributions and hazard ratio analyses were completed in this assessment.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOverall survival (OS) for both groups was similar; median OS for PET-only patients was 26.8 months compared with 22.4 months in PET-plus-invasive mediastinal staging (\u003Cem\u003EP\u003C\/em\u003E = .28). Both groups had similar rates of local recurrence-free survival (82.5% vs 89.6%), regional recurrence-free survival (89.5% vs 81.9%), and distant recurrence-free survival (78.2% vs 85.6%).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ENeither pretreatment staging method was predictive of OS or recurrence-free survival. Regression analysis showed that staging method type, prior cancer, age, and the presence of synchronous tumors were not significant predictors of OS or recurrence-free survival (\u003Cem\u003EP\u003C\/em\u003E \u0026gt; .05). However, central location (HR, 1.46) and advanced tumor stage (HR, 1.49) were factors that predicted worse OS (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .05).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe authors concluded that because of the similar clinical outcomes, more invasive mediastinal staging might be unnecessary for patients with early-stage NSCLC receiving SBRT.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/31\/16.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm1wd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}