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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EPatients with cervical cancer in whom magnetic resonance imaging identifies enlarged pelvic nodes may undergo further imaging with 18F-fluorodeoxyglucose positron emission tomography for further characterization. The study discussed in this article examines the impact of additional imaging on targeted radiation treatment and patient outcomes.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EReproductive Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EReproductive Cancers\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EReproductive Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EPrescreens for extrapelvic lymph node metastases using \u003Csup\u003E18\u003C\/sup\u003EF-fluorodeoxyglucose positron emission tomography (FDG-PET) did not enhance survival rate but reduced the use of extended-field concurrent chemoradiation (CCRT). Ji-Hong Hong, MD, PhD, Chang Gung Memorial Hospital, Taoyuan, Taiwan, presented results of this prospective phase 3 trial.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EPatients with cervical cancer in whom magnetic resonance imaging (MRI) identifies enlarged pelvic nodes may undergo further imaging with FDG-PET for further characterization. This study examined the impact of additional imaging on targeted radiation treatment and patient outcomes.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 129 patients recently diagnosed with stage I to IVA cervical cancer participated in this study and had MRI-confirmed positive pelvic and negative para-aortic lymph nodes (PALNs). Patients were randomized to either a study group (51%) receiving FDG-PET or a control group (49%) assessed only by MRI. The FDG-PET group received irradiation with fields based on extrapelvic findings, while the control group received irradiation of the whole pelvic field.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThere was no difference in freedom from extrapelvic metastasis between the FDG-PET and control groups (82.4% vs 75.8%, \u003Cem\u003EP\u003C\/em\u003E = .40). The 5-year survival rate for patients with relapse in the FDG-PET group was 0% compared with 30% in the control group. FDG-PET revealed extrapelvic metastases in 7 patients (11%), and PALN relapse occurred in 5 patients (8%). In the control group, 10 patients (16%) experienced PALN relapse.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe overall survival rate between groups was similar (68.2% vs 74.1%, \u003Cem\u003EP\u003C\/em\u003E = .55), as well as disease-free survival (66.8% vs 71.0%, \u003Cem\u003EP\u003C\/em\u003E = .72). Pretreatment FDG-PET showed that 18 patients had just a primary tumor; their disease-free survival rate of 94.5% was significantly better than that of all other patients.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe authors concluded that despite the lack of differences between the groups, the specificity of FDG-PET findings reduced the need for extended CCRT of nearby regions and can be a helpful pretreatment tool for targeted therapy.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/31\/12.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm1o1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}