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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ECurrent neoadjuvant chemoradiation therapy (nCRT) for locally advanced esophageal cancer (LAEC) consists of radiation with platinum\/5-FU (PF) chemotherapy. However, carboplatin\/paclitaxel (PT) may be a favorable chemotherapy combination with preoperative radiation. The study discussed in this article investigated whether nCRT with PT would result in better perioperative outcomes.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ENeoadjuvant chemoradiation therapy (nCRT) with carboplatin\/paclitaxel (PT) has similar perioperative outcomes as platinum\/5-FU (PF) in patients with locally advanced esophageal cancer (LAEC) but may have less toxicity. Abigail Berman, MD, University of Pennsylvania, Philadelphia, Pennsylvania, USA, presented findings from a retrospective analysis of patients with LAEC who were treated from 2008 to 2013.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ECurrent nCRT for LAEC consists of radiation with PF chemotherapy. However, PT may be a favorable chemotherapy combination with preoperative radiation. This study investigated whether nCRT with PT would result in better perioperative outcomes.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 100 consecutive patients were assessed; criteria included stage II to IV LAEC with a European Cooperative Oncology Group performance status of 0 to 1. The median radiation dose was 50.4 cGy (range, 45 to 59.4 cGy); 51% of patients received PF while 49% received PT. Most patients had adenocarcinoma (93%) of the esophagus and were male (86%) with a median age of 65 (range, 29 to 78). Follow-up assessments were examined, and perioperative complications were categorized as composite toxicity (hospital readmission) or acute toxicities in the pulmonary, cardiac, and gastrointestinal systems.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThere was no difference in overall survival in PF versus PT patients (76% vs 70%; \u003Cem\u003EP\u003C\/em\u003E = .70). Pathologic complete response was similar in patients treated with PF and PT (24% vs 25%; \u003Cem\u003EP\u003C\/em\u003E = .91). There were also comparable rates of locoregional recurrence (18% vs 10%; \u003Cem\u003EP\u003C\/em\u003E = .28) and distant metastases (22% vs 18%; \u003Cem\u003EP\u003C\/em\u003E = .65).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThere were no significant differences in baseline characteristics between the 2 groups or in pulmonary, cardiac, or gastrointestinal complications. However, patients treated with PF were readmitted more often than patients treated with PT (42% vs 22%; \u003Cem\u003EP\u003C\/em\u003E = .04).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThis study showed that PT nCRT and PF nCRT have comparable effects on a variety of outcomes. The authors concluded that reduced readmission rates suggest that PT may produce less composite toxicity during nCRT of LAEC.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/31\/15.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm01q\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}