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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EPreliminary findings demonstrate that patients with rectal cancer receiving radiotherapy with a combination of capecitabine and oxaliplatin have better local regional control compared with those receiving capecitabine plus radiotherapy. This article presents interim data from the ongoing phase 3 open-label Adjuvant Treatment of Concurrent R and CAPOX or Capecitabine Alone for Stage II and III Rectal Cancer trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00714077\u0026amp;atom=%2Fspmdc%2F14%2F31%2F10.atom\u0022\u003ENCT00714077\u003C\/a\u003E].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EGastrointestinal Cancers\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERadiation Therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EOncology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EPreliminary findings demonstrate that patients with rectal cancer receiving radiotherapy with a combination of capecitabine and oxaliplatin have better local regional control compared with those receiving capecitabine plus radiotherapy. Hua Ren, MD, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China, presented interim data from the ongoing phase 3 open-label Adjuvant Treatment of Concurrent R and CAPOX or Capecitabine Alone for Stage II and III Rectal Cancer trial [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00714077\u0026amp;atom=%2Fspmdc%2F14%2F31%2F10.atom\u0022\u003ENCT00714077\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe current postoperative therapy regimen for patients with advanced rectal cancer usually consists of radiotherapy and the chemotherapeutic agent capecitabine. It is unknown whether combination capecitabine and platinum-based chemotherapy has superior effects on clinical outcomes. This multicenter study assessed the efficacy and safety of these 2 chemoradiotherapy treatment regimens.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 414 patients with rectal cancer were stratified by their pathologic stage (II or III) and randomized 1:1 to either the capecitabine (Cap) group (190 patients) or the capecitabine\/oxaliplatin (CapOx) group (224 patients). Capecitabine was administered at 825 mg\/m\u003Csup\u003E2\u003C\/sup\u003E alone (Cap) or at 825 mg\/m\u003Csup\u003E2\u003C\/sup\u003E twice daily with 50 mg\/m\u003Csup\u003E2\u003C\/sup\u003E oxaliplatin at the beginning of each week (CapOx). All patients underwent radiotherapy at 50 Gy in 25 fractions with 2 dose cycles of concurrent chemotherapy. After 5 weeks of treatment, each group received 4 to 6 dose cycles of CapOx and fluorouracil.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EBy 3-year follow-up, there were no differences in disease-free survival rate in the Cap group compared with the CapOx group (71.79% vs 71.6%; \u003Cem\u003EP\u003C\/em\u003E = .799). Overall survival rates were also similar (89.0% vs 85.1%, \u003Cem\u003EP\u003C\/em\u003E = .916). Although there was no difference in cumulative metastatic rate (19.9% vs 20.7%, \u003Cem\u003EP\u003C\/em\u003E = .834), patients in the Cap group had a higher local recurrence rate than those in the CapOx group (8.1% vs 3.2%, \u003Cem\u003EP\u003C\/em\u003E = .034).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThere were no newly identified toxicities in either group. However, the Cap group had significantly fewer cases of thrombocytopenia (6.7% vs 14.2%, \u003Cem\u003EP\u003C\/em\u003E = .012) and fatigue (60.3% vs 71.8%, \u003Cem\u003EP\u003C\/em\u003E = .014).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe authors concluded that although there were significant differences in local recurrences, further patient recruitment is needed to obtain planned sample size calculations.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/31\/10.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzm01q\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}