RT Journal Article SR Electronic A1 Busse, Gregory T1 Evaluating the Effectiveness of Your Medication Choice JF MD Conference Express YR 2007 FD SAGE Publications VO 7 IS 2 SP 31 OP 32 DO 10.1177/155989770700700215 UL http://mdc.sagepub.com/content/7/2/31.abstract AB One significant issue facing patients currently on antidepressants is the loss of effect that may occur with chronic use of the drug, ie, the so called “poop-out” effect. This article elaborates on this issue and discusses true drug responders versus placebo responders (those that have responded to the non-specific effects of treatment). Despite their response to treatment, there are no available clinical indicators to differentiate between these two types of responders.