PT - JOURNAL ARTICLE AU - Busse, Gregory ED - Zimmerman, Mark TI - Evaluating the Effectiveness of Your Medication Choice DP - 2007 Aug 01 TA - MD Conference Express PG - 31--32 VI - 7 IP - 2 4099 - http://mdc.sagepub.com/content/7/2/31.short 4100 - http://mdc.sagepub.com/content/7/2/31.full AB - One significant issue facing patients currently on antidepressants is the loss of effect that may occur with chronic use of the drug, ie, the so called “poop-out” effect. This article elaborates on this issue and discusses true drug responders versus placebo responders (those that have responded to the non-specific effects of treatment). Despite their response to treatment, there are no available clinical indicators to differentiate between these two types of responders.